Kinetics of endocan in patients undergoing cardiac surgery with and without cardiopulmonary bypass.
Cytokine
; 110: 328-332, 2018 10.
Article
en En
| MEDLINE
| ID: mdl-29627158
ABSTRACT
BACKGROUND:
Endocan plays an important role in the processes of inflammation and infection. The use of cardiopulmonary bypass (CPB) during cardiac surgery can induce an inflammatory response. We aimed to describe the kinetics of endocan in patients undergoing cardiac surgery with and without the use of CPB.METHODS:
Single-centre, observational study with retrospective analysis of prospectively collected data, to compare the kinetics of endocan in patients undergoing isolated coronary artery bypass graft (CABG) surgery. Endocan was measured at induction of general anesthesia (baseline), and at 6, 24, 48 and 72â¯h after the end of surgery. Patients were classified into two groups, namely those undergoing CPB (CPB group) and those without CPB (off-pump group).RESULTS:
In total, 91 patients were included in thisanalysis:
61 patients in the CPB group and 30 in the off-pump group. There were no major significant differences between groups. Patients with CPB had a significantly higher level of endocan at 6â¯h (9.7⯱â¯6.7â¯ng/ml vs 6.9⯱â¯3.3â¯ng/ml, pâ¯=â¯0.03), but the difference was no longer statistically significant at subsequent timepoints. Endocan values were not significantly correlated with the duration of CPB (pâ¯=â¯0.53).CONCLUSION:
Endocan levels in patients undergoing isolated CABG surgery with CPB are significantly higher at 6â¯h than in patients with off-pump surgery, and peaks earlier in those with CPB (6â¯h) than in those undergoing off-pump surgery (24â¯h).Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteoglicanos
/
Vasos Coronarios
/
Proteínas de Neoplasias
Tipo de estudio:
Observational_studies
Límite:
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Cytokine
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Francia