InP/ZnS QDs exposure induces developmental toxicity in rare minnow (Gobiocypris rarus) embryos.
Environ Toxicol Pharmacol
; 60: 28-36, 2018 Jun.
Article
en En
| MEDLINE
| ID: mdl-29655014
ABSTRACT
We investigated the in vivo toxicity of InP/ZnS quantum dots (QDs) in Chinese rare minnow (Gobiocypris rarus) embryos. The 72â¯h post-fertilization (hpf) LC50 (median lethal concentration) was 1678.007â¯nmol/L. Rare minnows exposed to InP/ZnS QDs exhibited decreased spontaneous movement, decreased survival and hatchability rates, and an increased malformation rate. Pericardial edema, spinal curvature, bent tails and vitelline cysts were observed. Embryonic Wnt8a and Mstn mRNA levels were significantly up-regulated after InP/ZnS QDs treatment at 48â¯hpf (200â¯nmol/L) (pâ¯<â¯0.05). The superoxide dismutase (SOD) activity and malondialdehyde (MDA) levels at 96â¯hpf (800â¯nmol/L) had an increasing trend. Hsp70 mRNA expression was significantly changed at 48â¯hpf (200â¯nmol/L), but compared with the blank control, the different InP/ZnS QDs treatments did not significantly change the Olive tail moments (pâ¯>â¯0.05). Thus, InP/ZnS QDs caused teratogenic effects and death during the development of Chinese rare minnow embryos, but InP/ZnS QDs did not cause significant genetic toxicity during Chinese rare minnow development.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fosfinas
/
Sulfuros
/
Contaminantes Químicos del Agua
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Cyprinidae
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Compuestos de Zinc
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Puntos Cuánticos
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Embrión no Mamífero
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Indio
Límite:
Animals
Idioma:
En
Revista:
Environ Toxicol Pharmacol
Año:
2018
Tipo del documento:
Article