CuH-Catalyzed Asymmetric Hydroamidation of Vinylarenes.

Zhou, Yujing; Engl, Oliver D; Bandar, Jeffrey S; Chant, Emma D; Buchwald, Stephen L

Zhou, Yujing; Engl, Oliver D; Bandar, Jeffrey S; Chant, Emma D; Buchwald, Stephen L.

Afiliación

Zhou Y; Department of Chemistry, Room 18-490, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Engl OD; Department of Chemistry, Room 18-490, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Bandar JS; Department of Chemistry, Room 18-490, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Chant ED; Department of Chemistry, Room 18-490, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Buchwald SL; Department of Chemistry, Room 18-490, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

Angew Chem Int Ed Engl ; 57(22): 6672-6675, 2018 05 28.

Article en En | MEDLINE | ID: mdl-29660768

RESUMEN

A CuH-catalyzed enantioselective hydroamidation reaction of vinylarenes has been developed using readily accessible 1,4,2-dioxazol-5-ones as electrophilic amidating reagents. This method provides a straightforward and efficient approach to synthesize chiral amides in good yields with high levels of enantiopurity under mild conditions. Moreover, this transformation tolerates substrates bearing a broad range of functional groups.

Asunto(s)

Amidas/síntesis química; Cobre/química; Hidrógeno/química; Compuestos de Vinilo/química; Amidas/química; Catálisis; Estructura Molecular

Palabras clave

alkenes; amidation; amides; copper; enantioselectivity

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Vinilo / Cobre / Amidas / Hidrógeno Idioma: En Revista: Angew Chem Int Ed Engl Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos

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