3,7-Bis(2-hydroxyethyl)icaritin, a potent inhibitor of phosphodiesterase-5, prevents monocrotaline-induced pulmonary arterial hypertension via NO/cGMP activation in rats.

Lan, Tao-Hua; Chen, Xiao-Ling; Wu, Yun-Shan; Qiu, Hui-Liang; Li, Jun-Zhe; Ruan, Xin-Min; Xu, Dan-Ping; Lin, Dong-Qun

Lan, Tao-Hua; Chen, Xiao-Ling; Wu, Yun-Shan; Qiu, Hui-Liang; Li, Jun-Zhe; Ruan, Xin-Min; Xu, Dan-Ping; Lin, Dong-Qun.

Afiliación

Lan TH; Department of Cardiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 111 Dade Road, Guangzhou, PR China.
Chen XL; Department of Cardiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 111 Dade Road, Guangzhou, PR China.
Wu YS; Guangdong Provincial Hospital of Chinese Medicine, 111 Dade Road, Guangzhou, PR China.
Qiu HL; Department of Cardiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 111 Dade Road, Guangzhou, PR China.
Li JZ; Department of Cardiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 111 Dade Road, Guangzhou, PR China.
Ruan XM; Department of Cardiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 111 Dade Road, Guangzhou, PR China.
Xu DP; Department of Cardiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 111 Dade Road, Guangzhou, PR China.
Lin DQ; Department of Cardiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 111 Dade Road, Guangzhou, PR China. Electronic address: ldqtcm@163.com.

Eur J Pharmacol ; 829: 102-111, 2018 Jun 15.

Article en En | MEDLINE | ID: mdl-29665366

Asunto(s)

GMP Cíclico/metabolismo; Fosfodiesterasas de Nucleótidos Cíclicos Tipo 5/metabolismo; Flavonoides/farmacología; Hipertensión Pulmonar/metabolismo; Hipertensión Pulmonar/prevención & control; Monocrotalina/efectos adversos; Óxido Nítrico/metabolismo; Animales; GMP Cíclico/sangre; Endotelina-1/sangre; Endotelina-1/metabolismo; Hipertensión Pulmonar/inducido químicamente; Pulmón/efectos de los fármacos; Pulmón/metabolismo; Pulmón/fisiopatología; Masculino; Óxido Nítrico/sangre; Inhibidores de Fosfodiesterasa 5/farmacología; Ratas; Ratas Sprague-Dawley; Remodelación Vascular/efectos de los fármacos

Palabras clave

3,7-Bis(2-hydroxyethyl)icaritin; NO; PDE5 inhibitor; Pulmonary arterial hypertension; cGMP

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Flavonoides / Monocrotalina / GMP Cíclico / Fosfodiesterasas de Nucleótidos Cíclicos Tipo 5 / Hipertensión Pulmonar / Óxido Nítrico Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Eur J Pharmacol Año: 2018 Tipo del documento: Article

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