Sesquiterpenes and diterpenes with cytotoxic activities from the aerial parts of Carpesium humile.
Fitoterapia
; 128: 50-56, 2018 Jul.
Article
en En
| MEDLINE
| ID: mdl-29689329
ABSTRACT
Carpesium humile Winkl is an endemic Chinese species and no previous phytochemical studies have been reported for this species. Two new germacranolides (1 and 2) and a new phytane diterpene (5), together with five known compounds (two sesquiterpenoids and three diterpenoids), were isolated from the aerial parts of C. humile. Their structures were elucidated on the basis of extensive spectroscopic analysis. The conformations and absolute configurations of 1 and 2 were established by combinative analysis of NMR, CD exciton chirality, and X-ray crystallography data. Four germacranolides (1-4) showed strong cytotoxic activities, with broad spectrum activities against six human cancer (HepG2, HeLa, HL60, SGC7901, Lewis, and MDA231) cell lines in vitro using MTT assay, with IC50 values from 3.09 to 7.71⯵g/mL. Diterpenes (5, 6, and 8) also displayed good cytotoxic activities for selected cancer cell lines, with IC50 values in the range 5.46-8.08⯵g/mL.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Asteraceae
/
Sesquiterpenos de Germacrano
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Diterpenos
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Antineoplásicos Fitogénicos
Límite:
Humans
Idioma:
En
Revista:
Fitoterapia
Año:
2018
Tipo del documento:
Article