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Discovery and Optimization of Indolyl-Containing 4-Hydroxy-2-Pyridone Type II DNA Topoisomerase Inhibitors Active against Multidrug Resistant Gram-negative Bacteria.
Gerasyuto, Aleksey I; Arnold, Michael A; Wang, Jiashi; Chen, Guangming; Zhang, Xiaoyan; Smith, Sean; Woll, Matthew G; Baird, John; Zhang, Nanjing; Almstead, Neil G; Narasimhan, Jana; Peddi, Srinivasa; Dumble, Melissa; Sheedy, Josephine; Weetall, Marla; Branstrom, Arthur A; Prasad, J V N; Karp, Gary M.
Afiliación
  • Gerasyuto AI; PTC Therapeutics, Inc. , 100 Corporate Court , South Plainfield , New Jersey 07080 , United States.
  • Arnold MA; PTC Therapeutics, Inc. , 100 Corporate Court , South Plainfield , New Jersey 07080 , United States.
  • Wang J; PTC Therapeutics, Inc. , 100 Corporate Court , South Plainfield , New Jersey 07080 , United States.
  • Chen G; PTC Therapeutics, Inc. , 100 Corporate Court , South Plainfield , New Jersey 07080 , United States.
  • Zhang X; PTC Therapeutics, Inc. , 100 Corporate Court , South Plainfield , New Jersey 07080 , United States.
  • Smith S; PTC Therapeutics, Inc. , 100 Corporate Court , South Plainfield , New Jersey 07080 , United States.
  • Woll MG; PTC Therapeutics, Inc. , 100 Corporate Court , South Plainfield , New Jersey 07080 , United States.
  • Baird J; PTC Therapeutics, Inc. , 100 Corporate Court , South Plainfield , New Jersey 07080 , United States.
  • Zhang N; PTC Therapeutics, Inc. , 100 Corporate Court , South Plainfield , New Jersey 07080 , United States.
  • Almstead NG; PTC Therapeutics, Inc. , 100 Corporate Court , South Plainfield , New Jersey 07080 , United States.
  • Narasimhan J; PTC Therapeutics, Inc. , 100 Corporate Court , South Plainfield , New Jersey 07080 , United States.
  • Peddi S; PTC Therapeutics, Inc. , 100 Corporate Court , South Plainfield , New Jersey 07080 , United States.
  • Dumble M; PTC Therapeutics, Inc. , 100 Corporate Court , South Plainfield , New Jersey 07080 , United States.
  • Sheedy J; PTC Therapeutics, Inc. , 100 Corporate Court , South Plainfield , New Jersey 07080 , United States.
  • Weetall M; PTC Therapeutics, Inc. , 100 Corporate Court , South Plainfield , New Jersey 07080 , United States.
  • Branstrom AA; PTC Therapeutics, Inc. , 100 Corporate Court , South Plainfield , New Jersey 07080 , United States.
  • Prasad JVN; PTC Therapeutics, Inc. , 100 Corporate Court , South Plainfield , New Jersey 07080 , United States.
  • Karp GM; PTC Therapeutics, Inc. , 100 Corporate Court , South Plainfield , New Jersey 07080 , United States.
J Med Chem ; 61(10): 4456-4475, 2018 05 24.
Article en En | MEDLINE | ID: mdl-29727185
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ADN-Topoisomerasas de Tipo II / Sepsis / Farmacorresistencia Bacteriana Múltiple / Descubrimiento de Drogas / Inhibidores de Topoisomerasa II / Bacterias Gramnegativas / Antibacterianos Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ADN-Topoisomerasas de Tipo II / Sepsis / Farmacorresistencia Bacteriana Múltiple / Descubrimiento de Drogas / Inhibidores de Topoisomerasa II / Bacterias Gramnegativas / Antibacterianos Límite: Animals Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos