Targeting arginase and nitric oxide metabolism in chronic airway diseases and their co-morbidities.
Curr Opin Pharmacol
; 40: 126-133, 2018 06.
Article
en En
| MEDLINE
| ID: mdl-29729549
ABSTRACT
In the airways, arginase and NOS compete for the common substrate l-arginine. In chronic airway diseases, such as asthma and COPD, elevated arginase expression contributes to airway contractility, hyperresponsiveness, inflammation and remodeling. The disrupted l-arginine homeostasis, through changes in arginase and NOS expression and activity, does not only play a central role in the development of various airways diseases such as asthma or COPD. It possibly also affects l-arginine homeostasis throughout the body contributing to the emergence of co-morbidities. This review focusses on the role of arginase, NOS and ADMA in co-morbidities of asthma and COPD and speculates on their possible connection.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Arginasa
/
Asma
/
Óxido Nítrico Sintasa
/
Antiasmáticos
/
Enfermedad Pulmonar Obstructiva Crónica
/
Inhibidores Enzimáticos
/
Pulmón
/
Antiinflamatorios
/
Óxido Nítrico
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Pharmacol
Asunto de la revista:
FARMACOLOGIA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Países Bajos