Anti-neuroinflammatory effects of 20C from Gastrodia elata via regulating autophagy in LPS-activated BV-2 cells through MAPKs and TLR4/Akt/mTOR signaling pathways.

Shao, Qian-Hang; Zhang, Xiao-Ling; Chen, Ying; Zhu, Cheng-Gen; Shi, Jian-Gong; Yuan, Yu-He; Chen, Nai-Hong

Shao, Qian-Hang; Zhang, Xiao-Ling; Chen, Ying; Zhu, Cheng-Gen; Shi, Jian-Gong; Yuan, Yu-He; Chen, Nai-Hong.

Afiliación

Shao QH; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Zhang XL; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Chen Y; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Zhu CG; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Shi JG; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Yuan YH; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: yuanyuhe@imm.ac.cn.
Chen NH; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; College of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hu

Mol Immunol ; 99: 115-123, 2018 07.

Article en En | MEDLINE | ID: mdl-29763880

Asunto(s)

Antiinflamatorios/farmacología; Autofagia/efectos de los fármacos; Compuestos de Bencidrilo/farmacología; Gastrodia/química; Proteínas Quinasas Activadas por Mitógenos/metabolismo; Fenoles/farmacología; Proteínas Proto-Oncogénicas c-akt/metabolismo; Serina-Treonina Quinasas TOR/metabolismo; Receptor Toll-Like 4/metabolismo; Animales; Proteínas Relacionadas con la Autofagia/metabolismo; Línea Celular; Inflamación/inducido químicamente; Inflamación/tratamiento farmacológico; Inflamación/metabolismo; Lipopolisacáridos/farmacología; Ratones; Fosforilación/efectos de los fármacos; Transducción de Señal/efectos de los fármacos

Palabras clave

20C; Autophagy; Mechanistic target of rapamycin (mTOR); Mitogen-activated protein kinases (MAPKs); Protein kinase B (Akt); Toll like receptor 4 (TLR4)

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoles / Autofagia / Compuestos de Bencidrilo / Proteínas Quinasas Activadas por Mitógenos / Gastrodia / Proteínas Proto-Oncogénicas c-akt / Receptor Toll-Like 4 / Serina-Treonina Quinasas TOR / Antiinflamatorios Límite: Animals Idioma: En Revista: Mol Immunol Año: 2018 Tipo del documento: Article País de afiliación: China

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