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[The expressions and correlations of IL-10, CD14 and CD68 in laryngal squamous cell carcinoma].
Zhang, S; Huangfu, H; Wang, B Q; Gao, W; Wu, L N; Li, Y; Li, W Y.
Afiliación
  • Zhang S; Department of Otolaryngology Head and Neck Surgery, the First Hospital of Shanxi Medical University, Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, Key Institute and Laboratory of Otolaryngology Affiliated with Shanxi Province, Taiyuan, 030001, China.
  • Huangfu H; Department of Otolaryngology Head and Neck Surgery, the First Hospital of Shanxi Medical University, Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, Key Institute and Laboratory of Otolaryngology Affiliated with Shanxi Province, Taiyuan, 030001, China.
  • Wang BQ; Department of Otolaryngology Head and Neck Surgery, the First Hospital of Shanxi Medical University, Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, Key Institute and Laboratory of Otolaryngology Affiliated with Shanxi Province, Taiyuan, 030001, China.
  • Gao W; Department of Otolaryngology Head and Neck Surgery, the First Hospital of Shanxi Medical University, Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, Key Institute and Laboratory of Otolaryngology Affiliated with Shanxi Province, Taiyuan, 030001, China.
  • Wu LN; Department of Pathology, the First Hospital of Shanxi Medical University.
  • Li Y; Department of Otolaryngology Head and Neck Surgery, the First Hospital of Shanxi Medical University, Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, Key Institute and Laboratory of Otolaryngology Affiliated with Shanxi Province, Taiyuan, 030001, China.
  • Li WY; Department of Otolaryngology Head and Neck Surgery, the First Hospital of Shanxi Medical University, Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, Key Institute and Laboratory of Otolaryngology Affiliated with Shanxi Province, Taiyuan, 030001, China.
Article en Zh | MEDLINE | ID: mdl-29774998
Objective:The aim of this study is to investigate the distribution of IL-10, CD14 and CD68 in the tumor microenvironment of LSCC with the clinicopathologic factors. Method:We detected the expressions of IL-10, CD14 and CD68 in 46 primary LSCC tumor tissues by immunohistochemistry staining and explore the relationship between them and clinicopathologic factors. Result:We found that the expressions of IL-10, CD14 and CD68 were significantly correlated with clinical stage and T stage (P<0.01). IL-10 and CD14 were correlated with lymph node metastasis (P<0.01), and CD68 was correlated with pathological differentiation (P<0.05). There is a positive correlation trend between the expression of IL-10 and CD14 (P<0.01). Conclusion:We confirm that the high level expressions of IL-10, monocytes and TAMs contribute to the tumor development of LSCC and there is a positive correlation between the expression of IL-10 and monocytes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Antígenos de Diferenciación Mielomonocítica / Biomarcadores de Tumor / Antígenos CD / Neoplasias Laríngeas / Interleucina-10 / Receptores de Lipopolisacáridos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: Zh Revista: Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi Año: 2017 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Antígenos de Diferenciación Mielomonocítica / Biomarcadores de Tumor / Antígenos CD / Neoplasias Laríngeas / Interleucina-10 / Receptores de Lipopolisacáridos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: Zh Revista: Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi Año: 2017 Tipo del documento: Article País de afiliación: China
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