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Evaluation of 4ß-Hydroxycholesterol and 25-Hydroxycholesterol as Endogenous Biomarkers of CYP3A4: Study with CYP3A-Humanized Mice.
Nitta, Shin-Ichiro; Hashimoto, Mari; Kazuki, Yasuhiro; Takehara, Shoko; Suzuki, Hiraku; Oshimura, Mitsuo; Akita, Hidetaka; Chiba, Kan; Kobayashi, Kaoru.
Afiliación
  • Nitta SI; Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan.
  • Hashimoto M; LSI Medience Corporation, 3-30-1 Shimura, Itabashi-ku, Tokyo, 174-8555, Japan.
  • Kazuki Y; Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan.
  • Takehara S; Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, 86 Nishi-cho, Yonago, Tottori, 683-8503, Japan.
  • Suzuki H; Chromosome Engineering Research Center (CERC), Tottori University, 86 Nishi-cho, Yonago, Tottori, 683-8503, Japan.
  • Oshimura M; Chromosome Engineering Research Center (CERC), Tottori University, 86 Nishi-cho, Yonago, Tottori, 683-8503, Japan.
  • Akita H; LSI Medience Corporation, 3-30-1 Shimura, Itabashi-ku, Tokyo, 174-8555, Japan.
  • Chiba K; Chromosome Engineering Research Center (CERC), Tottori University, 86 Nishi-cho, Yonago, Tottori, 683-8503, Japan.
  • Kobayashi K; Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan.
AAPS J ; 20(3): 61, 2018 04 09.
Article en En | MEDLINE | ID: mdl-29858698
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Sistema Enzimático del Citocromo P-450 / Citocromo P-450 CYP3A / Hidroxicolesteroles Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: AAPS J Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2018 Tipo del documento: Article País de afiliación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Sistema Enzimático del Citocromo P-450 / Citocromo P-450 CYP3A / Hidroxicolesteroles Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: AAPS J Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2018 Tipo del documento: Article País de afiliación: Japón