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A minimal physiologically based pharmacokinetic model that predicts anti-PEG IgG-mediated clearance of PEGylated drugs in human and mouse.
McSweeney, M D; Wessler, T; Price, L S L; Ciociola, E C; Herity, L B; Piscitelli, J A; Zamboni, W C; Forest, M G; Cao, Y; Lai, S K.
Afiliación
  • McSweeney MD; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA. Electronic address: morgan_mcsweeney@unc.edu.
  • Wessler T; Department of Mathematics, University of North Carolina, Chapel Hill, NC, USA. Electronic address: wessler@live.unc.edu.
  • Price LSL; Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA. Electronic address: lslprice@email.unc.edu.
  • Ciociola EC; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA. Electronic address: lciociol@live.unc.edu.
  • Herity LB; Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA. Electronic address: herity@email.unc.edu.
  • Piscitelli JA; Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA. Electronic address: joseph_piscitelli@unc.edu.
  • Zamboni WC; Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA. Electronic address: zamboni@email.unc.edu.
  • Forest MG; Department of Mathematics, University of North Carolina, Chapel Hill, NC, USA. Electronic address: forest@unc.edu.
  • Cao Y; Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA. Electronic address: yanguang@unc.edu.
  • Lai SK; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA; UNC/NCSU Joint Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC, USA; Department of Microbiology and Immunology, School of
J Control Release ; 284: 171-178, 2018 08 28.
Article en En | MEDLINE | ID: mdl-29879519
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polietilenglicoles / Urato Oxidasa / Inmunoglobulina G / Anticuerpos Antiidiotipos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: J Control Release Asunto de la revista: FARMACOLOGIA Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polietilenglicoles / Urato Oxidasa / Inmunoglobulina G / Anticuerpos Antiidiotipos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: J Control Release Asunto de la revista: FARMACOLOGIA Año: 2018 Tipo del documento: Article