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Sterol 14α-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis.
Friggeri, Laura; Hargrove, Tatiana Y; Wawrzak, Zdzislaw; Blobaum, Anna L; Rachakonda, Girish; Lindsley, Craig W; Villalta, Fernando; Nes, W David; Botta, Maurizio; Guengerich, F Peter; Lepesheva, Galina I.
Afiliación
  • Friggeri L; Department of Biochemistry , Vanderbilt University School of Medicine , Nashville , Tennessee 37232 , United States.
  • Hargrove TY; Department of Biochemistry , Vanderbilt University School of Medicine , Nashville , Tennessee 37232 , United States.
  • Wawrzak Z; Synchrotron Research Center, Life Science Collaborative Access Team , Northwestern University , Argonne , Illinois 60439 , United States.
  • Blobaum AL; Vanderbilt Center for Neuroscience Drug Discovery , Franklin , Tennessee 37067 , United States.
  • Rachakonda G; Department of Microbiology, Immunology, and Physiology , Meharry Medical College , Nashville , Tennessee 37208 , United States.
  • Lindsley CW; Vanderbilt Center for Neuroscience Drug Discovery , Franklin , Tennessee 37067 , United States.
  • Villalta F; Department of Microbiology, Immunology, and Physiology , Meharry Medical College , Nashville , Tennessee 37208 , United States.
  • Nes WD; Department of Chemistry and Biochemistry , Texas Tech University , Lubbock , Texas 79409 , United States.
  • Botta M; Department of Biotechnology, Chemistry and Pharmacy , University of Siena , Siena 53100 , Italy.
  • Guengerich FP; Department of Biochemistry , Vanderbilt University School of Medicine , Nashville , Tennessee 37232 , United States.
  • Lepesheva GI; Department of Biochemistry , Vanderbilt University School of Medicine , Nashville , Tennessee 37232 , United States.
J Med Chem ; 61(13): 5679-5691, 2018 07 12.
Article en En | MEDLINE | ID: mdl-29894182
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_chagas_disease Asunto principal: Aspergillus fumigatus / Candida albicans / Diseño de Fármacos / Esterol 14-Desmetilasa / Imidazoles Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_chagas_disease Asunto principal: Aspergillus fumigatus / Candida albicans / Diseño de Fármacos / Esterol 14-Desmetilasa / Imidazoles Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos