Optical monitoring of adipose tissue destruction under encapsulated lipase action.
J Biophotonics
; 11(11): e201800058, 2018 11.
Article
en En
| MEDLINE
| ID: mdl-29900686
ABSTRACT
Enzymatic destruction of adipose tissue has been achieved by encapsulation of lipase into the polymeric microcapsules. Adipose tissue destruction was delayed while lipase is encapsulated comparing with the direct lipase action as demonstrated by optical microscopy and optical coherence tomography in in vitro studies. Raman spectroscopy confirms that triglycerides in fat tissue were cleaved into free fatty acids, glycerol, and possible di- and monoglyceride residues. The results underpin the concept of local and controlled treatment of tissues via encapsulation. Effect of lipase encapsulation into the polymeric microcapsules on adipose tissue destruction compared to free lipase application.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Espectrometría Raman
/
Proteínas Fúngicas
/
Tejido Adiposo
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Tomografía de Coherencia Óptica
/
Lipasa
Límite:
Humans
Idioma:
En
Revista:
J Biophotonics
Asunto de la revista:
BIOFISICA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Rusia