CD46 is a potent co-stimulatory receptor for expansion of human IFN-γ-producing CD8+ T cells.
Immunol Lett
; 200: 26-32, 2018 08.
Article
en En
| MEDLINE
| ID: mdl-29902483
ABSTRACT
Similar to CD4+ T cells, precursor CD8+ T cells are thought to depend on a co-stimulatory signal through CD28 for proliferation and differentiation into effector cells. CD46 is another co-stimulatory receptor that promotes differentiation of CD4+ T-helper cells type 1 (Th1 cells) into a regulatory phenotype with a switch from IFN-γ towards IL-10-secretion over time. Whether CD46 exerts a similar function on CD8+ T cells remains to be fully elucidated. Here, we demonstrate that CD46 co-stimulation induced secretion of IFN-γ as well as expansion of IFN-γ-secreting CD8+ T cells. In contrast to CD46 co-stimulation of CD4+ T cells, CD8+ T cells did not differentiate into a regulatory IL-10-secreting phenotype. This demonstrates that CD46 is a co-stimulatory receptor on CD8+ T cells, and that it exerts separate functions during CD4+ and CD8+ T-cell differentiation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Activación de Linfocitos
/
Interferón gamma
/
Linfocitos T CD8-positivos
/
Proteína Cofactora de Membrana
Límite:
Humans
Idioma:
En
Revista:
Immunol Lett
Año:
2018
Tipo del documento:
Article
País de afiliación:
Dinamarca