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Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator.
Wang, Chi; Aleksandrov, Andrei A; Yang, Zhengrong; Forouhar, Farhad; Proctor, Elizabeth A; Kota, Pradeep; An, Jianli; Kaplan, Anna; Khazanov, Netaly; Boël, Grégory; Stockwell, Brent R; Senderowitz, Hanoch; Dokholyan, Nikolay V; Riordan, John R; Brouillette, Christie G; Hunt, John F.
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  • Wang C; From the Departments of Biological Sciences.
  • Aleksandrov AA; Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599.
  • Yang Z; Department of Chemistry, University of Alabama, Birmingham, Alabama 35294.
  • Forouhar F; From the Departments of Biological Sciences.
  • Proctor EA; Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599.
  • Kota P; Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599.
  • An J; Department of Chemistry, University of Alabama, Birmingham, Alabama 35294.
  • Kaplan A; From the Departments of Biological Sciences.
  • Khazanov N; Department of Chemistry, Bar-Ilan University, Ramat-Gan 5290002, Israel.
  • Boël G; From the Departments of Biological Sciences.
  • Stockwell BR; From the Departments of Biological Sciences; Chemistry, Columbia University, New York, New York 10027.
  • Senderowitz H; Department of Chemistry, Bar-Ilan University, Ramat-Gan 5290002, Israel.
  • Dokholyan NV; Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599.
  • Riordan JR; Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599.
  • Brouillette CG; Department of Chemistry, University of Alabama, Birmingham, Alabama 35294.
  • Hunt JF; From the Departments of Biological Sciences. Electronic address: jfh21@columbia.edu.
J Biol Chem ; 293(46): 17685-17704, 2018 11 16.
Article en En | MEDLINE | ID: mdl-29903914
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nucleótidos de Timina / Regulador de Conductancia de Transmembrana de Fibrosis Quística Límite: Humans Idioma: En Revista: J Biol Chem Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nucleótidos de Timina / Regulador de Conductancia de Transmembrana de Fibrosis Quística Límite: Humans Idioma: En Revista: J Biol Chem Año: 2018 Tipo del documento: Article