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Postnatal Exocrine Pancreas Growth by Cellular Hypertrophy Correlates with a Shorter Lifespan in Mammals.
Anzi, Shira; Stolovich-Rain, Miri; Klochendler, Agnes; Fridlich, Ori; Helman, Aharon; Paz-Sonnenfeld, Avital; Avni-Magen, Nili; Kaufman, Elizabeth; Ginzberg, Miriam B; Snider, Daniel; Ray, Saikat; Brecht, Michael; Holmes, Melissa M; Meir, Karen; Avivi, Aaron; Shams, Imad; Berkowitz, Asaf; Shapiro, A M James; Glaser, Benjamin; Ben-Sasson, Shmuel; Kafri, Ran; Dor, Yuval.
Afiliación
  • Anzi S; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
  • Stolovich-Rain M; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
  • Klochendler A; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
  • Fridlich O; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
  • Helman A; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
  • Paz-Sonnenfeld A; The Tisch Family Zoological Gardens in Jerusalem, Box 898, Manhat, Jerusalem 91008, Israel.
  • Avni-Magen N; The Tisch Family Zoological Gardens in Jerusalem, Box 898, Manhat, Jerusalem 91008, Israel.
  • Kaufman E; The Tisch Family Zoological Gardens in Jerusalem, Box 898, Manhat, Jerusalem 91008, Israel.
  • Ginzberg MB; The Hospital for Sick Children, University of Toronto, ON, Canada.
  • Snider D; The Hospital for Sick Children, University of Toronto, ON, Canada.
  • Ray S; Bernstein Center for Computational Neuroscience, Humboldt University of Berlin, Berlin, Germany.
  • Brecht M; Bernstein Center for Computational Neuroscience, Humboldt University of Berlin, Berlin, Germany.
  • Holmes MM; Department of Psychology, University of Toronto Mississauga, Mississauga, ON, Canada.
  • Meir K; Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel.
  • Avivi A; Institute of Evolution, University of Haifa, Haifa, Israel.
  • Shams I; Institute of Evolution, University of Haifa, Haifa, Israel.
  • Berkowitz A; Department of Pathology, Kimron Veterinary Institute, Beit Dagan, Israel.
  • Shapiro AMJ; Department of Surgery, University of Alberta, Edmonton, AB, Canada.
  • Glaser B; Endocrinology and Metabolism Service, Department of Internal Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
  • Ben-Sasson S; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
  • Kafri R; The Hospital for Sick Children, University of Toronto, ON, Canada.
  • Dor Y; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel. Electronic address: yuvald@ekmd.huji.ac.il.
Dev Cell ; 45(6): 726-737.e3, 2018 06 18.
Article en En | MEDLINE | ID: mdl-29920277
Developmental processes in different mammals are thought to share fundamental cellular mechanisms. We report a dramatic increase in cell size during postnatal pancreas development in rodents, accounting for much of the increase in organ size after birth. Hypertrophy of pancreatic acinar cells involves both higher ploidy and increased biosynthesis per genome copy; is maximal adjacent to islets, suggesting endocrine to exocrine communication; and is partly driven by weaning-related processes. In contrast to the situation in rodents, pancreas cell size in humans remains stable postnatally, indicating organ growth by pure hyperplasia. Pancreatic acinar cell volume varies 9-fold among 24 mammalian species analyzed, and shows a striking inverse correlation with organismal lifespan. We hypothesize that cellular hypertrophy is a strategy for rapid postnatal tissue growth, entailing life-long detrimental effects.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tamaño de los Órganos / Páncreas Límite: Animals / Humans Idioma: En Revista: Dev Cell Asunto de la revista: EMBRIOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Israel

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tamaño de los Órganos / Páncreas Límite: Animals / Humans Idioma: En Revista: Dev Cell Asunto de la revista: EMBRIOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Israel
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