Halogenated quinolines bearing polar functionality at the 2-position: Identification of new antibacterial agents with enhanced activity against Staphylococcus epidermidis.

Basak, Akash; Abouelhassan, Yasmeen; Kim, Young S; Norwood, Verrill M; Jin, Shouguang; Huigens, Robert W

Basak, Akash; Abouelhassan, Yasmeen; Kim, Young S; Norwood, Verrill M; Jin, Shouguang; Huigens, Robert W.

Afiliación

Basak A; Department of Chemistry, University of Florida, United States.
Abouelhassan Y; Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery & Development (CNPD3), College of Pharmacy, University of Florida, United States.
Kim YS; Department of Molecular Genetics & Microbiology, College of Medicine, University of Florida, United States.
Norwood VM; Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery & Development (CNPD3), College of Pharmacy, University of Florida, United States.
Jin S; Department of Molecular Genetics & Microbiology, College of Medicine, University of Florida, United States.
Huigens RW; Department of Chemistry, University of Florida, United States; Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery & Development (CNPD3), College of Pharmacy, University of Florida, United States. Electronic address: rhuigens@cop.ufl.edu.

Eur J Med Chem ; 155: 705-713, 2018 Jul 15.

Article en En | MEDLINE | ID: mdl-29936357

Asunto(s)

Antibacterianos/farmacología; Quinolinas/farmacología; Staphylococcus epidermidis/efectos de los fármacos; Antibacterianos/síntesis química; Antibacterianos/química; Supervivencia Celular/efectos de los fármacos; Relación Dosis-Respuesta a Droga; Eritrocitos/efectos de los fármacos; Halogenación; Células HeLa; Humanos; Pruebas de Sensibilidad Microbiana; Estructura Molecular; Quinolinas/síntesis química; Quinolinas/química; Relación Estructura-Actividad

Palabras clave

Antibacterial agents; Biofilm eradication; Chemical synthesis; Drug discovery; Halogenated quinolines; Staphylococcus epidermidis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quinolinas / Staphylococcus epidermidis / Antibacterianos Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos

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