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Identification of a PDE4-Specific Pocket for the Design of Selective Inhibitors.
Feng, Xiaoqing; Wang, Huanchen; Ye, Mengchun; Xu, Xue-Tao; Xu, Ying; Yang, Wenzhe; Zhang, Han-Ting; Song, Guoqiang; Ke, Hengming.
Afiliación
  • Feng X; School of Pharmaceutical Engineering and Life Sciences , Changzhou University , Changzhou , Jiangsu 213164 , P. R. China.
  • Wang H; Department of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center , The University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599-7260 , United States.
  • Ye M; Department of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center , The University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599-7260 , United States.
  • Xu XT; Signal Transduction Laboratory, National Institute of Environmental Health Sciences , National Institutes of Health , 111 Alexander Drive , Research Triangle Park , North Carolina 27709 , United States.
  • Xu Y; Department of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center , The University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599-7260 , United States.
  • Yang W; School of Chemical and Environmental Engineering , Wuyi University , Jiangmen , Guangdong 529020 , P. R. China.
  • Zhang HT; School of Chemical and Environmental Engineering , Wuyi University , Jiangmen , Guangdong 529020 , P. R. China.
  • Song G; Departments of Behavioral Medicine and Psychiatry, Physiology, Pharmacology, and Neuroscience and Rockefeller Neurosciences Institute , West Virginia University Health Sciences Center , Morgantown , West Virginia 26506-9137 , United States.
  • Ke H; Department of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center , The University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599-7260 , United States.
Biochemistry ; 57(30): 4518-4525, 2018 07 31.
Article en En | MEDLINE | ID: mdl-29975048
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Éteres Fenílicos / Diseño de Fármacos / Fosfodiesterasas de Nucleótidos Cíclicos Tipo 4 / Inhibidores de Fosfodiesterasa 4 / Furanos Tipo de estudio: Diagnostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Biochemistry Año: 2018 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Éteres Fenílicos / Diseño de Fármacos / Fosfodiesterasas de Nucleótidos Cíclicos Tipo 4 / Inhibidores de Fosfodiesterasa 4 / Furanos Tipo de estudio: Diagnostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Biochemistry Año: 2018 Tipo del documento: Article