ProTide generated long-acting abacavir nanoformulations.

Lin, Zhiyi; Gautam, Nagsen; Alnouti, Yazen; McMillan, JoEllyn; Bade, Aditya N; Gendelman, Howard E; Edagwa, Benson

Lin, Zhiyi; Gautam, Nagsen; Alnouti, Yazen; McMillan, JoEllyn; Bade, Aditya N; Gendelman, Howard E; Edagwa, Benson.

Afiliación

Lin Z; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-5880, USA. hegendel@unmc.edu benson.edagwa@unmc.edu.

Chem Commun (Camb) ; 54(60): 8371-8374, 2018 Jul 24.

Article en En | MEDLINE | ID: mdl-29995046

RESUMEN

Abacavir pronucleotide nanoformulations (NM3ABC) were prepared as a novel long acting slow effective release antiretroviral therapy. Single NM3ABC treatment of human monocyte-derived macrophages produced sustained intracellular carbovir-triphosphate and antiretroviral activities for up to 30 days.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article

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