[Acquired aplastic anemia. Experience in a public hospital]. / Aplasia medular adquirida, experiencia en un hospital público de referencia.
Rev Med Chil
; 146(2): 175-182, 2018 Feb.
Article
en Es
| MEDLINE
| ID: mdl-29999153
ABSTRACT
BACKGROUND:
The first line treatment for patients < 40 years old with aplastic anemia (AA) is allogeneic HLA-identical sibling donor transplantation (SCT). Immunosuppressive therapy (IST) with a combination of Thymoglobuline (ATG) and cyclosporine is used for older patients or those without a donor. Five year overall survival (OS) for both therapies is > 70%.AIM:
To report the experience with SCT and ATG for AA in a public hospital. PATIENTS ANDMETHODS:
AA was diagnosed in 42 patients between 1998 and 2016, according to Camitta criteria. Thirty eight (90%) received treatment, 7 (18%) under 40 years old received SCT, and 31 (82%) IST. The rest were not treated. OS was calculated from date of diagnosis until last control, death or loss from follow up.RESULTS:
Complete or partial hematologic response, was obtained in 71% and 58% of cases with SCT and IS, respectively. Five year OS was 71% and 55% with SCT and IST, respectively. No difference in response was observed between horse and rabbit ATG.CONCLUSIONS:
SCT from an HLA-identical sibling donor had a high response rate and survival. IST instead, had a lower response and survival, due to an initial high mortality rate.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
6_ODS3_enfermedades_notrasmisibles
Problema de salud:
6_other_blood_disorders
Asunto principal:
Ciclosporina
/
Trasplante de Células Madre
/
Inmunosupresores
/
Anemia Aplásica
/
Suero Antilinfocítico
Límite:
Adolescent
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Adult
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Aged
/
Aged80
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Humans
/
Middle aged
Idioma:
Es
Revista:
Rev Med Chil
Año:
2018
Tipo del documento:
Article
País de afiliación:
Chile