Oncogene-specific T cells fail to eradicate lymphoma-initiating B cells in mice.
Blood
; 132(9): 924-934, 2018 08 30.
Article
en En
| MEDLINE
| ID: mdl-30002144
ABSTRACT
To date, little is known about the interaction between (pre-)malignant B cells and T cells. We generated transgenic mice that allow B cell-specific induction of the oncogene SV40 large T-antigen (TAg) to analyze the role of oncogene-specific T cells during sporadic B-cell lymphoma development. Constitutive TAg expression in CD19-Cre × LoxP-Tag mice resulted in TAg-tolerant CD8+ T cells and development of B-cell lymphomas. In contrast, CD19-CreERT2 × LoxP-Tag mice retained TAg-competent CD8+ T cells at time of oncogene induction and TAg expression in few B cells of adult mice resulted in exceptionally rare lymphoma formation late in life. Increased lymphoma incidence in the absence of TAg-specific T cells suggested T cell-mediated inhibition of lymphoma progression. However, TAg-initiated B cells were not eliminated by T cells and detected long term. Our results demonstrate a failure of the immune system to eradicate lymphoma-initiating B cells, retaining the risk of lymphoma development.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfocitos B
/
Antígenos Transformadores de Poliomavirus
/
Linfoma de Células B
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Linfocitos T CD8-positivos
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Inmunidad Celular
Límite:
Animals
Idioma:
En
Revista:
Blood
Año:
2018
Tipo del documento:
Article
País de afiliación:
Alemania