The effect of tinea versicolor on thiol/disulphide homeostasis.
Postepy Dermatol Alergol
; 35(3): 299-303, 2018 Jun.
Article
en En
| MEDLINE
| ID: mdl-30008649
ABSTRACT
INTRODUCTION:
Tinea versicolor is a superficial fungal infection caused by Malassezia spp. Malassezia spp. is a member of the normal human skin flora. It becomes a pathogen by transforming from the yeast form to the mycelium form. The oxidant/antioxidant homeostasis may be responsible for this. Thiol/disulphide homeostasis is a new marker indicating oxidative stress. This homeostasis is affected in many illnesses.AIM:
To investigate the thiol/disulphide homeostasis in patients with tinea versicolor. MATERIAL ANDMETHODS:
Forty-two patients with tinea versicolor (median age 36 years, min.-max. 19-58) and 36 healthy controls (median age 32 years, min.-max. 18-60) were included in the trial. The levels of native thiol, disulphide, and total thiol were measured by an automated method in the patient and control groups. Disulphide/total thiol, disulphide/native thiol and native thiol/total thiol rates were calculated as percentage.RESULTS:
For the patient group and the control group, the native thiol levels were found to be 464.32 ±51.48 mmol/l and 465.18 ±51.32 mmol/l, disulphide levels - 19.80 ±7.08 mmol/l and 21.27 ±8.90 mmol/l, total thiol levels - 503.92 ±53.65 mmol/l and 508.07 ±56.59 mmol/l, respectively. No statistical difference was detected between the two groups.CONCLUSIONS:
Thiol/disulphide homeostasis was not affected in tinea versicolor. According to our findings, oxidative stress seems to have no role in the pathogenesis of tinea versicolor.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Postepy Dermatol Alergol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Turquía