Intracellular Ca2+ Release and Synaptic Plasticity: A Tale of Many Stores.
Neuroscientist
; 25(3): 208-226, 2019 06.
Article
en En
| MEDLINE
| ID: mdl-30014771
ABSTRACT
Ca2+ is an essential trigger for most forms of synaptic plasticity. Ca2+ signaling occurs not only by Ca2+ entry via plasma membrane channels but also via Ca2+ signals generated by intracellular organelles. These organelles, by dynamically regulating the spatial and temporal extent of Ca2+ elevations within neurons, play a pivotal role in determining the downstream consequences of neural signaling on synaptic function. Here, we review the role of three major intracellular stores the endoplasmic reticulum, mitochondria, and acidic Ca2+ stores, such as lysosomes, in neuronal Ca2+ signaling and plasticity. We provide a comprehensive account of how Ca2+ release from these stores regulates short- and long-term plasticity at the pre- and postsynaptic terminals of central synapses.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sinapsis
/
Señalización del Calcio
/
Plasticidad Neuronal
/
Neuronas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Neuroscientist
Asunto de la revista:
NEUROLOGIA
/
PSIQUIATRIA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Reino Unido