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Vielopsides A-E, five new guaiane-type sesquiterpenoid dimers from Xylopia vielana.
Xie, Yang-Guo; Wu, Guo-Jing; Cheng, Tao-Fang; Zhu, Sheng-Lan; Yan, Shi-Kai; Jin, Hui-Zi; Zhang, Wei-Dong.
Afiliación
  • Xie YG; Shanghai Key Laboratory of Antimicrobias, New Drug Discovery, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China.
  • Wu GJ; Shanghai Key Laboratory of Antimicrobias, New Drug Discovery, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China.
  • Cheng TF; Shanghai Key Laboratory of Antimicrobias, New Drug Discovery, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China.
  • Zhu SL; Shanghai Key Laboratory of Antimicrobias, New Drug Discovery, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China.
  • Yan SK; Shanghai Key Laboratory of Antimicrobias, New Drug Discovery, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China.
  • Jin HZ; Shanghai Key Laboratory of Antimicrobias, New Drug Discovery, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China. Electronic address: kimhz@sjtu.edu.cn.
  • Zhang WD; Shanghai Key Laboratory of Antimicrobias, New Drug Discovery, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China; School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China. Electronic address: wdzhangy@hotmail.com.
Fitoterapia ; 130: 43-47, 2018 Oct.
Article en En | MEDLINE | ID: mdl-30076886
ABSTRACT
Five new guaiane-type sesquiterpenoid dimers vielopsides A-E, connecting patterns through two direct CC bonds (C-2 to C-2', C-4 to C-1'), were isolated from the roots of Xylopia vielana. Their absolute configurations were established by NOE analysis, the Cu Kα X-ray crystallographic and circular dichroism (CD) experiment. Among them, compound 5 showed moderate activity IC50 values of 33.8 µM on NO production in RAW 264.7 macrophages.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sesquiterpenos / Xylopia / Fitoquímicos Límite: Animals País/Región como asunto: Asia Idioma: En Revista: Fitoterapia Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sesquiterpenos / Xylopia / Fitoquímicos Límite: Animals País/Región como asunto: Asia Idioma: En Revista: Fitoterapia Año: 2018 Tipo del documento: Article