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Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies.
Brindisi, Margherita; Senger, Johanna; Cavella, Caterina; Grillo, Alessandro; Chemi, Giulia; Gemma, Sandra; Cucinella, Dora Mariagrazia; Lamponi, Stefania; Sarno, Federica; Iside, Concetta; Nebbioso, Angela; Novellino, Ettore; Shaik, Tajith Baba; Romier, Christophe; Herp, Daniel; Jung, Manfred; Butini, Stefania; Campiani, Giuseppe; Altucci, Lucia; Brogi, Simone.
Afiliación
  • Brindisi M; European Research Centre for Drug Discovery and Development (NatSynDrugs) and Department of Biotechnology, Chemistry, and Pharmacy, Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100, Siena, Italy.
  • Senger J; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Albertstraße 25, 79104, Freiburg, Germany.
  • Cavella C; European Research Centre for Drug Discovery and Development (NatSynDrugs) and Department of Biotechnology, Chemistry, and Pharmacy, Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100, Siena, Italy.
  • Grillo A; European Research Centre for Drug Discovery and Development (NatSynDrugs) and Department of Biotechnology, Chemistry, and Pharmacy, Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100, Siena, Italy.
  • Chemi G; European Research Centre for Drug Discovery and Development (NatSynDrugs) and Department of Biotechnology, Chemistry, and Pharmacy, Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100, Siena, Italy.
  • Gemma S; European Research Centre for Drug Discovery and Development (NatSynDrugs) and Department of Biotechnology, Chemistry, and Pharmacy, Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100, Siena, Italy.
  • Cucinella DM; European Research Centre for Drug Discovery and Development (NatSynDrugs) and Department of Biotechnology, Chemistry, and Pharmacy, Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100, Siena, Italy.
  • Lamponi S; European Research Centre for Drug Discovery and Development (NatSynDrugs) and Department of Biotechnology, Chemistry, and Pharmacy, Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100, Siena, Italy.
  • Sarno F; Department of Biochemistry, Biophysics & General Pathology, Second University of Napoli, Vico Luigi De Crecchio 7, 80138, Napoli, Italy; Institute of Genetics and Biophysics Adriano Buzzati-Traverso, IGB-CNR, Via Pietro Castellino 111, 80131, Napoli, Italy.
  • Iside C; Department of Biochemistry, Biophysics & General Pathology, Second University of Napoli, Vico Luigi De Crecchio 7, 80138, Napoli, Italy; Institute of Genetics and Biophysics Adriano Buzzati-Traverso, IGB-CNR, Via Pietro Castellino 111, 80131, Napoli, Italy.
  • Nebbioso A; Department of Biochemistry, Biophysics & General Pathology, Second University of Napoli, Vico Luigi De Crecchio 7, 80138, Napoli, Italy; Institute of Genetics and Biophysics Adriano Buzzati-Traverso, IGB-CNR, Via Pietro Castellino 111, 80131, Napoli, Italy.
  • Novellino E; Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131, Napoli, Italy.
  • Shaik TB; Département de Biologie Structurale Intégrative, Institut de Génétique et Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UDS), CNRS, INSERM, 67404, Illkirch Cedex, France.
  • Romier C; Département de Biologie Structurale Intégrative, Institut de Génétique et Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UDS), CNRS, INSERM, 67404, Illkirch Cedex, France.
  • Herp D; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Albertstraße 25, 79104, Freiburg, Germany.
  • Jung M; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Albertstraße 25, 79104, Freiburg, Germany.
  • Butini S; European Research Centre for Drug Discovery and Development (NatSynDrugs) and Department of Biotechnology, Chemistry, and Pharmacy, Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100, Siena, Italy. Electronic address: butini3@unisi.it.
  • Campiani G; European Research Centre for Drug Discovery and Development (NatSynDrugs) and Department of Biotechnology, Chemistry, and Pharmacy, Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100, Siena, Italy. Electronic address: campiani@unisi.it.
  • Altucci L; Department of Biochemistry, Biophysics & General Pathology, Second University of Napoli, Vico Luigi De Crecchio 7, 80138, Napoli, Italy; Institute of Genetics and Biophysics Adriano Buzzati-Traverso, IGB-CNR, Via Pietro Castellino 111, 80131, Napoli, Italy.
  • Brogi S; European Research Centre for Drug Discovery and Development (NatSynDrugs) and Department of Biotechnology, Chemistry, and Pharmacy, Department of Excellence 2018-2022, University of Siena, via Aldo Moro 2, 53100, Siena, Italy.
Eur J Med Chem ; 157: 127-138, 2018 Sep 05.
Article en En | MEDLINE | ID: mdl-30092367
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Histona Desacetilasa 1 / Inhibidores de Histona Desacetilasas / Histona Desacetilasa 6 / Antineoplásicos Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2018 Tipo del documento: Article País de afiliación: Italia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Histona Desacetilasa 1 / Inhibidores de Histona Desacetilasas / Histona Desacetilasa 6 / Antineoplásicos Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2018 Tipo del documento: Article País de afiliación: Italia