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Reducing Dendrimer Generation and PEG Chain Length Increases Drug Release and Promotes Anticancer Activity of PEGylated Polylysine Dendrimers Conjugated with Doxorubicin via a Cathepsin-Cleavable Peptide Linker.
Mehta, Dharmini; Leong, Nathania; McLeod, Victoria M; Kelly, Brian D; Pathak, Rashmi; Owen, David J; Porter, Christopher J H; Kaminskas, Lisa M.
Afiliación
  • Mehta D; Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences , Monash University , 381 Royal Parade , Parkville , Victoria 3052 , Australia.
  • Leong N; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences , Monash University , 381 Royal Parade , Parkville , Victoria 3052 , Australia.
  • McLeod VM; Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences , Monash University , 381 Royal Parade , Parkville , Victoria 3052 , Australia.
  • Kelly BD; Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences , Monash University , 381 Royal Parade , Parkville , Victoria 3052 , Australia.
  • Pathak R; Starpharma Pty Ltd. , 4-6 Southampton Cresent , Abbotsford , Victoria 3067 , Australia.
  • Owen DJ; Starpharma Pty Ltd. , 4-6 Southampton Cresent , Abbotsford , Victoria 3067 , Australia.
  • Porter CJH; Starpharma Pty Ltd. , 4-6 Southampton Cresent , Abbotsford , Victoria 3067 , Australia.
  • Kaminskas LM; Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences , Monash University , 381 Royal Parade , Parkville , Victoria 3052 , Australia.
Mol Pharm ; 15(10): 4568-4576, 2018 10 01.
Article en En | MEDLINE | ID: mdl-30107748
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 Problema de salud: 1_medicamentos_vacinas_tecnologias Asunto principal: Polilisina / Doxorrubicina / Catepsinas / Dendrímeros Límite: Animals / Humans / Male Idioma: En Revista: Mol Pharm Asunto de la revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Australia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 Problema de salud: 1_medicamentos_vacinas_tecnologias Asunto principal: Polilisina / Doxorrubicina / Catepsinas / Dendrímeros Límite: Animals / Humans / Male Idioma: En Revista: Mol Pharm Asunto de la revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Australia