The heat shock protein 47 as a potential biomarker and a therapeutic agent in cancer research.
J Cancer Res Clin Oncol
; 144(12): 2319-2328, 2018 Dec.
Article
en En
| MEDLINE
| ID: mdl-30128672
ABSTRACT
Heat shock protein 47 (HSP47) is an important chaperone required for the correct folding and secretion of collagen. Several studies revealed that HSP47 has a role in numerous steps of collagen synthesis, preventing procollagen aggregation and inducing hydroxylation of proline and lysine residues. HSP47 is encoded by the SERPINH1 gene, which is located on chromosome 11q13.5, one of the most frequently amplified regions in human cancer. The altered expression levels of HSP47 have been correlated with several types of cancer, such as cervical, breast, pancreatic and gastric cancers. Studies have shown that HSP47 promotes tumor angiogenesis, growth, migration and metastatic capacity. In this review, we highlight the fundamental aspects of the interaction between HSP47 and collagen and the recent discoveries of the role of this chaperone in different types of malignant neoplasias. We also discuss recent treatments using HSP47 as a therapeutic target, and present evidences that HSP47 is an essential protein for cancer biology and a potential molecular target for chemotherapy.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Biomarcadores de Tumor
/
Proteínas del Choque Térmico HSP47
/
Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Cancer Res Clin Oncol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Brasil