Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer.

Nagathihalli, Nagaraj S; Castellanos, Jason A; Lamichhane, Purushottam; Messaggio, Fanuel; Shi, Chanjuan; Dai, Xizi; Rai, Priyamvada; Chen, Xi; VanSaun, Michael N; Merchant, Nipun B

Nagathihalli, Nagaraj S; Castellanos, Jason A; Lamichhane, Purushottam; Messaggio, Fanuel; Shi, Chanjuan; Dai, Xizi; Rai, Priyamvada; Chen, Xi; VanSaun, Michael N; Merchant, Nipun B.

Afiliación

Nagathihalli NS; Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida.
Castellanos JA; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida.
Lamichhane P; Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee.
Messaggio F; Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida.
Shi C; Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida.
Dai X; Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee.
Rai P; Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida.
Chen X; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida.
VanSaun MN; Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida.
Merchant NB; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida.

Cancer Res ; 78(21): 6235-6246, 2018 11 01.

Article en En | MEDLINE | ID: mdl-30154150

Asunto(s)

MAP Quinasa Quinasa 1/metabolismo; Neoplasias Pancreáticas/tratamiento farmacológico; Neoplasias Pancreáticas/metabolismo; Factor de Transcripción STAT3/metabolismo; Proteínas ras/metabolismo; Anfirregulina/metabolismo; Animales; Carcinoma Ductal Pancreático/metabolismo; Carcinoma Ductal Pancreático/patología; Línea Celular Tumoral; Femenino; Regulación Neoplásica de la Expresión Génica; Humanos; Ligandos; Ratones; Ratones Desnudos; Mutación; Trasplante de Neoplasias; Fosforilación; Proteínas Proto-Oncogénicas p21(ras)/metabolismo; Transducción de Señal; Análisis de Matrices Tisulares; Microambiente Tumoral

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Proteínas ras / MAP Quinasa Quinasa 1 / Factor de Transcripción STAT3 Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Cancer Res Año: 2018 Tipo del documento: Article

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