Pink1/Parkin link inflammation, mitochondrial stress, and neurodegeneration.
J Cell Biol
; 217(10): 3327-3329, 2018 10 01.
Article
en En
| MEDLINE
| ID: mdl-30154188
ABSTRACT
What causes inflammation in age-related neurodegenerative diseases remains a mystery. Sliter et al. (2018. Nature https//doi.org/10.1038/s41586-018-0448-9) show that, when damaged mitochondria cannot be removed by mitophagy, stress from exercise or mitochondrial DNA mutations activates the proinflammatory cGAS-STING pathway that may contribute to Parkinson's disease.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Quinasas
/
Mitofagia
Límite:
Humans
Idioma:
En
Revista:
J Cell Biol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Canadá