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Involvement of interleukin-31 receptor A in morphine-induced itching and antinociception in mice.
Tsuji, Minoru; Arai, Iwao; Miyagawa, Kazuya; Miyagishi, Hiroko; Saito, Atsumi; Takeda, Kotaro; Takeda, Hiroshi; Akiyama, Nobutake; Saito, Saburo.
Afiliación
  • Tsuji M; Department of Pharmacology, School of Pharmacy, International University of Health and Welfare, Ohtawara, Tochigi, Japan.
  • Arai I; Department of Pharmacology, School of Pharmacy, International University of Health and Welfare, Ohtawara, Tochigi, Japan.
  • Miyagawa K; Department of Molecular Immunology, Institute of DNA medicine, Jikei University, Tokyo, Japan.
  • Miyagishi H; Department of Pharmacology, School of Pharmacy, International University of Health and Welfare, Ohtawara, Tochigi, Japan.
  • Saito A; Department of Pharmacology, School of Pharmacy, International University of Health and Welfare, Ohtawara, Tochigi, Japan.
  • Takeda K; Department of Pharmacology, School of Pharmacy, International University of Health and Welfare, Ohtawara, Tochigi, Japan.
  • Takeda H; Department of Pharmacology, School of Pharmacy, International University of Health and Welfare, Ohtawara, Tochigi, Japan.
  • Akiyama N; Department of Pharmacology, School of Pharmacy, International University of Health and Welfare, Ohtawara, Tochigi, Japan.
  • Saito S; Department of Molecular Immunology, Institute of DNA medicine, Jikei University, Tokyo, Japan.
Eur J Pain ; 23(2): 378-388, 2019 02.
Article en En | MEDLINE | ID: mdl-30176108
ABSTRACT

BACKGROUND:

Morphine is an effective analgesic for the treatment of severe pain, but it can cause itching in patients. In the present study, we examined the possible involvement of interleukin-31 (IL-31) receptor A (IL-31RA) on the morphine-induced itching and antinociception in mice.

METHODS:

Long-lasting scratching (LLS) and short-lasting scratching (SLS) were estimated as an indicator of itching and nonspecific behaviour, respectively, and antinociception was evaluated using a hot-plate test in mice.

RESULTS:

Morphine (5 mg/kg, s.c.) induced multiple episodes of SLS, few episodes of LLS, and antinociception in naive mice, with a close correlation observed between SLS or LLS counts and antinociception. In IL-31RA-deficient (IL-31RA-/- ) mice, morphine (5 mg/kg, s.c.)-induced LLS but not SLS was completely abolished, while antinociception was partially suppressed with 2.5 and 5 mg/kg but not 10 mg/kg, s.c. of morphine administration. Interestingly, intracerebroventricular (i.c.v.) administration of morphine (10 µg/mouse) significantly increased SLS but not LLS, and this effect was higher in IL-31RA-/- mice than that in wild-type mice. Furthermore, following i.c.v. administration of morphine (10 µg/mouse), the antinociceptive effect was also significantly higher in IL-31RA-/- mice than that in wild-type mice.

CONCLUSION:

Taken together, the present findings suggest that IL-31RA may play a significant role, perhaps in the sensory neurons and/or spinal cord rather than in the brain, in the modulation of morphine-induced itching and antinociception.

SIGNIFICANCE:

Here, we demonstrate a possible common mediator of itching and antinociception of morphine, interleukin-31 (IL-31) receptor A (IL-31RA). IL-31RA may be a noteworthy target for considering the novel mechanism of itch and pain signalling affected by morphine.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor / Prurito / Receptores de Interleucina / Analgésicos Opioides / Morfina Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Eur J Pain Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Japón

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor / Prurito / Receptores de Interleucina / Analgésicos Opioides / Morfina Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Eur J Pain Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Japón
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