GABPß1L Wakes Up TERT.
Cancer Cell
; 34(3): 358-360, 2018 09 10.
Article
en En
| MEDLINE
| ID: mdl-30205042
ABSTRACT
TERT catalyzes telomere maintenance. While silenced in most normal somatic cells, TERT is expressed in cancer, often due to promoter mutations, facilitating replicative immortality. In this issue of Cancer Cell, Mancini et al. demonstrate that GABPß1L is required for mutant TERT promoter activity, thus identifying a potential therapeutic target.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Glioblastoma
/
Telomerasa
Límite:
Humans
Idioma:
En
Revista:
Cancer Cell
Asunto de la revista:
NEOPLASIAS
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos