GABPß1L Wakes Up TERT.

Rahme, Gilbert J; Gaskell, Elizabeth; Bernstein, Bradley E

Rahme, Gilbert J; Gaskell, Elizabeth; Bernstein, Bradley E.

Afiliación

Rahme GJ; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Gaskell E; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Bernstein BE; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: bernstein.bradley@mgh.harvard.edu.

Cancer Cell ; 34(3): 358-360, 2018 09 10.

Article en En | MEDLINE | ID: mdl-30205042

ABSTRACT

ABSTRACT

TERT catalyzes telomere maintenance. While silenced in most normal somatic cells, TERT is expressed in cancer, often due to promoter mutations, facilitating replicative immortality. In this issue of Cancer Cell, Mancini et al. demonstrate that GABPß1L is required for mutant TERT promoter activity, thus identifying a potential therapeutic target.

Asunto(s)

Glioblastoma; Telomerasa/genética; Humanos; Mutación; Regiones Promotoras Genéticas; Isoformas de Proteínas

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glioblastoma / Telomerasa Límite: Humans Idioma: En Revista: Cancer Cell Asunto de la revista: NEOPLASIAS Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos

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