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HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα.
Di Rita, Anthea; Peschiaroli, Angelo; D Acunzo, Pasquale; Strobbe, Daniela; Hu, Zehan; Gruber, Jens; Nygaard, Mads; Lambrughi, Matteo; Melino, Gerry; Papaleo, Elena; Dengjel, Jörn; El Alaoui, Said; Campanella, Michelangelo; Dötsch, Volker; Rogov, Vladimir V; Strappazzon, Flavie; Cecconi, Francesco.
Afiliación
  • Di Rita A; Department of Biology, University of Rome Tor Vergata, 00133, Rome, Italy.
  • Peschiaroli A; Department of Paediatric Haematology, Oncology and Cell and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
  • D Acunzo P; IRCCS FONDAZIONE SANTA LUCIA, 00143, Rome, Italy.
  • Strobbe D; National Research Council of Italy (CNR), Institute of Translational Pharmacology IFT, Via Fosso del Cavaliere 100, 00133, Rome, Italy.
  • Hu Z; Department of Paediatric Haematology, Oncology and Cell and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
  • Gruber J; Department of Biology, University of Rome Tor Vergata, 00133, Rome, Italy.
  • Nygaard M; IRCCS- Regina Elena, National Cancer Institute, 00133, Rome, Italy.
  • Lambrughi M; Department of Biology, University of Fribourg, Fribourg, Switzerland.
  • Melino G; Institute of Biophysical and Center for Biomolecular Magnetic Resonance, Goethe University, Frankfurt, Germany.
  • Papaleo E; Computational Biology Laboratory, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.
  • Dengjel J; Computational Biology Laboratory, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.
  • El Alaoui S; Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, 00133, Rome, Italy.
  • Campanella M; Computational Biology Laboratory, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.
  • Dötsch V; Department of Biology, University of Fribourg, Fribourg, Switzerland.
  • Rogov VV; Covalab, Villeurbanne, France.
  • Strappazzon F; IRCCS- Regina Elena, National Cancer Institute, 00133, Rome, Italy.
  • Cecconi F; Department of Comparative Biomedical Sciences, Royal Veterinary College, London, NW1 0TU, UK.
Nat Commun ; 9(1): 3755, 2018 09 14.
Article en En | MEDLINE | ID: mdl-30217973
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Supresoras de Tumor / Ubiquitina-Proteína Ligasas / Proteínas Adaptadoras Transductoras de Señales / Quinasa I-kappa B / Mitofagia Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2018 Tipo del documento: Article País de afiliación: Italia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Supresoras de Tumor / Ubiquitina-Proteína Ligasas / Proteínas Adaptadoras Transductoras de Señales / Quinasa I-kappa B / Mitofagia Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2018 Tipo del documento: Article País de afiliación: Italia