Extrasynaptic &#945;<sub>5</sub>GABA<sub>A</sub> receptors on proprioceptive afferents produce a tonic depolarization that modulates sodium channel function in the rat spinal cord.

Lucas-Osma, Ana M; Li, Yaqing; Lin, Shihao; Black, Sophie; Singla, Rahul; Fouad, Karim; Fenrich, Keith K; Bennett, David J

Extrasynaptic α₅GABA_A receptors on proprioceptive afferents produce a tonic depolarization that modulates sodium channel function in the rat spinal cord.

Lucas-Osma, Ana M; Li, Yaqing; Lin, Shihao; Black, Sophie; Singla, Rahul; Fouad, Karim; Fenrich, Keith K; Bennett, David J.

Afiliación

Lucas-Osma AM; Neuroscience and Mental Health Institute and Faculty of Rehabilitation Medicine, University of Alberta , Edmonton, AB , Canada.
Li Y; Neuroscience and Mental Health Institute and Faculty of Rehabilitation Medicine, University of Alberta , Edmonton, AB , Canada.
Lin S; Neuroscience and Mental Health Institute and Faculty of Rehabilitation Medicine, University of Alberta , Edmonton, AB , Canada.
Black S; Neuroscience and Mental Health Institute and Faculty of Rehabilitation Medicine, University of Alberta , Edmonton, AB , Canada.
Singla R; Neuroscience and Mental Health Institute and Faculty of Rehabilitation Medicine, University of Alberta , Edmonton, AB , Canada.
Fouad K; Neuroscience and Mental Health Institute and Faculty of Rehabilitation Medicine, University of Alberta , Edmonton, AB , Canada.
Fenrich KK; Neuroscience and Mental Health Institute and Faculty of Rehabilitation Medicine, University of Alberta , Edmonton, AB , Canada.
Bennett DJ; Neuroscience and Mental Health Institute and Faculty of Rehabilitation Medicine, University of Alberta , Edmonton, AB , Canada.

J Neurophysiol ; 120(6): 2953-2974, 2018 12 01.

Article en En | MEDLINE | ID: mdl-30256739

Asunto(s)

Potenciales de la Membrana; Neuronas Aferentes/metabolismo; Propiocepción; Receptores de GABA-A/metabolismo; Canales de Sodio/metabolismo; Médula Espinal/metabolismo; Animales; Femenino; Antagonistas de Receptores de GABA-A/farmacología; Inhibición Neural; Neuronas Aferentes/efectos de los fármacos; Neuronas Aferentes/fisiología; Ratas; Ratas Sprague-Dawley; Médula Espinal/citología; Médula Espinal/fisiología; Sinapsis/metabolismo; Sinapsis/fisiología

Palabras clave

GABA; antidromic action potential; branch point failure; dorsal root; dorsal root reflex; extrasynaptic; intracellular recording; primary afferent depolarization; spinal cord

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Propiocepción / Médula Espinal / Canales de Sodio / Receptores de GABA-A / Potenciales de la Membrana / Neuronas Aferentes Límite: Animals Idioma: En Revista: J Neurophysiol Año: 2018 Tipo del documento: Article País de afiliación: Canadá

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