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Innervation of the Epithelium and Lamina Propria of the Urethra of the Female Rat.
Eggermont, Monica; De Wachter, Stefan; Eastham, Jane; Gillespie, James.
Afiliación
  • Eggermont M; Department of Urology, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
  • De Wachter S; Department of Urology, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
  • Eastham J; Uro-physiology Research Group, The Dental and Medical School, Newcastle University, Newcastle upon Tyne, UK.
  • Gillespie J; Department of Urology, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Anat Rec (Hoboken) ; 302(2): 201-214, 2019 02.
Article en En | MEDLINE | ID: mdl-30290399
ABSTRACT
The aim of this study was to characterize the number, type and distribution of immunochemically identified nerves in epithelium and lamina propria of the female rat urethra. Urethras from female Sprague-Dawley rats (n = 12) were fixed, frozen and sectioned (8 µm). Standard immunohistochemical techniques were used to identify putative nerves using the following antibodies calcitonin gene related peptide (cgrp), neuronal nitric oxide synthase (nNos), tyrosine hydroxylase (TH) and vesicular acetylcholine transporter (vacht). The number, distribution and characteristics of all immunoreactive (IR) structures adjacent to the urethral epithelium and in the lamina propria was assessed. In the bladder, few cgrp-IR and vacht-IR fibers were associated with the urothelium or suburothelium of the lateral wall. In contrast, large numbers of vacht-IR, nNos-IR and cgrp-IR fibers were found close to the epithelium and subepithelium of the bladder neck and throughout the urethra. The number of cgrp-IR fibers was significantly higher in the urethra in comparison with the bladder neck. A population of undescribed cgrp-IR cells associated with the bladder neck and proximal urethra has been characterized. Each of these cells appears to be associated with a nerve fiber. In the distal urethra, the number of peptidergic fibers penetrating the epithelium was significantly higher than the rest of the urethra. Clearly, this study has revealed a highly complex and heterogeneous network of putative afferent nerves fibers along the length of the urethra. These structural specializations need to be taken into account when probing the different functions of the urethra. Anat Rec, 302201-214, 2019. © 2018 Wiley Periodicals, Inc.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Uretra / Biomarcadores / Epitelio / Membrana Mucosa Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Anat Rec (Hoboken) Asunto de la revista: ANATOMIA Año: 2019 Tipo del documento: Article País de afiliación: Bélgica

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Uretra / Biomarcadores / Epitelio / Membrana Mucosa Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Anat Rec (Hoboken) Asunto de la revista: ANATOMIA Año: 2019 Tipo del documento: Article País de afiliación: Bélgica
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