Your browser doesn't support javascript.
loading
TAT-mGluR1 Attenuation of Neuronal Apoptosis through Prevention of MGluR1α Truncation after Experimental Subarachnoid Hemorrhage.
Wang, Weiqi; Han, Ping; Xie, Rongxia; Yang, Mingfeng; Zhang, Cheng; Mi, Qiongjie; Sun, Baoliang; Zhang, Zongyong.
Afiliación
  • Wang W; Medical College of Qingdao University , Qingdao 266021 , Shandong , People's Republic of China.
  • Han P; Key Lab of Cerebral Microcirculation at the Universities of Shandong, Department of Neurology , Affiliated Hospital of Taishan Medical University , Taian 271016 , Shandong , People's Republic of China.
  • Xie R; Key Lab of Cerebral Microcirculation at the Universities of Shandong, Department of Neurology , Affiliated Hospital of Taishan Medical University , Taian 271016 , Shandong , People's Republic of China.
  • Yang M; Key Lab of Cerebral Microcirculation at the Universities of Shandong, Department of Neurology , Affiliated Hospital of Taishan Medical University , Taian 271016 , Shandong , People's Republic of China.
  • Zhang C; Department of Neurology , Central Hospital of Xinwen Mining Group , Taian 271000 , People's Republic of China.
  • Mi Q; Key Lab of Cerebral Microcirculation at the Universities of Shandong, Department of Neurology , Affiliated Hospital of Taishan Medical University , Taian 271016 , Shandong , People's Republic of China.
  • Sun B; Key Lab of Cerebral Microcirculation at the Universities of Shandong, Department of Neurology , Affiliated Hospital of Taishan Medical University , Taian 271016 , Shandong , People's Republic of China.
  • Zhang Z; Key Lab of Cerebral Microcirculation at the Universities of Shandong, Department of Neurology , Affiliated Hospital of Taishan Medical University , Taian 271016 , Shandong , People's Republic of China.
ACS Chem Neurosci ; 10(1): 746-756, 2019 01 16.
Article en En | MEDLINE | ID: mdl-30339347
ABSTRACT
Excessive glutamate-mediated overactivation of metabotropic glutamate receptor 1 (mGluR1) plays a leading role in neuronal apoptosis following subarachnoid hemorrhage (SAH). TAT-mGluR1, a fusion peptide consisting of a peptide spanning the calpain cleavage site of mGluR1α and the trans-activating regulatory protein (TAT) of HIV, effectively blocks mGluR1α truncation and protects neurons against excitotoxic damage. This study investigated the effects of TAT-mGluR1 on neuronal apoptosis in the rat SAH model. Here, we report that SAH caused activation of calpain and truncation of mGluR1α; intraperitoneally administered TAT-mGluR1 did not affect calpain activity, while it blocked truncation of mGluR1α after SAH. Intraperitoneally administered FITC-labeled TAT-mGluR1 was colocalized with mGluR1α in thecortex after SAH. Furthermore, TAT-mGluR1 significantly improved the neurological deficit, increased p-PI3K, p-Akt, and p-GSK3ß, downregulated Bax, upregulated Bcl-2, and reduced cortical apoptosis in the basal cortex at 24 h after SAH. These findings indicated that TAT-mGluR1 acted against SAH-induced cell apoptosis through preventing mGluR1α truncation.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 / 6_ODS3_enfermedades_notrasmisibles Problema de salud: 1_doencas_nao_transmissiveis / 6_cardiovascular_diseases / 6_cerebrovascular_disease Asunto principal: Hemorragia Subaracnoidea / Receptores de Glutamato Metabotrópico / Fármacos Neuroprotectores Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: ACS Chem Neurosci Año: 2019 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 / 6_ODS3_enfermedades_notrasmisibles Problema de salud: 1_doencas_nao_transmissiveis / 6_cardiovascular_diseases / 6_cerebrovascular_disease Asunto principal: Hemorragia Subaracnoidea / Receptores de Glutamato Metabotrópico / Fármacos Neuroprotectores Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: ACS Chem Neurosci Año: 2019 Tipo del documento: Article
...