Development of DNA-Compatible Suzuki-Miyaura Reaction in Aqueous Media.
Bioconjug Chem
; 29(11): 3841-3846, 2018 11 21.
Article
en En
| MEDLINE
| ID: mdl-30339361
ABSTRACT
DNA-encoded chemical libraries (DELs) are a cost-effective technology for the discovery of novel chemical probes and drug candidates. A major limiting factor in assembling productive DELs is the availability of DNA-compatible chemical reactions in aqueous media. In an effort to increase the chemical accessibility and structural diversity of small molecules displayed by DELs, we developed a robust Suzuki-Miyaura reaction protocol that is compatible with the DNA structures. By employing a water-soluble Pd-precatalyst, we developed conditions that allow efficient coupling of DNA-linked aryl halides with a wide variety of boronic acids/esters including heteroaryl boronates.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ácidos Borónicos
/
ADN
/
Agua
/
Bibliotecas de Moléculas Pequeñas
/
Hidrocarburos Aromáticos
Idioma:
En
Revista:
Bioconjug Chem
Asunto de la revista:
BIOQUIMICA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos