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Production of "biobetter" glucarpidase variants to improve drug detoxification and antibody directed enzyme prodrug therapy for cancer treatment.
AlQahtani, Alanod D; Al-Mansoori, Layla; Bashraheel, Sara S; Rashidi, Fatma B; Al-Yafei, Afrah; Elsinga, Philip; Domling, Alexander; Goda, Sayed K.
Afiliación
  • AlQahtani AD; Protein Engineering Unit, Life and Science Research Department, Anti-Doping Lab-Qatar (ADLQ), Doha, Qatar; Drug Design Group, Department of Pharmacy, University of Groningen, Groningen, the Netherlands.
  • Al-Mansoori L; Protein Engineering Unit, Life and Science Research Department, Anti-Doping Lab-Qatar (ADLQ), Doha, Qatar; University of Groningen University, Medical Center Groningen (UMCG), Groningen, the Netherlands.
  • Bashraheel SS; Protein Engineering Unit, Life and Science Research Department, Anti-Doping Lab-Qatar (ADLQ), Doha, Qatar; Drug Design Group, Department of Pharmacy, University of Groningen, Groningen, the Netherlands.
  • Rashidi FB; Cairo University, Faculty of Science, Chemistry Department, Giza, Egypt. Electronic address: fabdallah@adlqatar.qa.
  • Al-Yafei A; Protein Engineering Unit, Life and Science Research Department, Anti-Doping Lab-Qatar (ADLQ), Doha, Qatar.
  • Elsinga P; University of Groningen University, Medical Center Groningen (UMCG), Groningen, the Netherlands.
  • Domling A; Drug Design Group, Department of Pharmacy, University of Groningen, Groningen, the Netherlands.
  • Goda SK; Protein Engineering Unit, Life and Science Research Department, Anti-Doping Lab-Qatar (ADLQ), Doha, Qatar. Electronic address: Sgoda@Adlqatar.qa.
Eur J Pharm Sci ; 127: 79-91, 2019 Jan 15.
Article en En | MEDLINE | ID: mdl-30343151
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polietilenglicoles / Profármacos / Gamma-Glutamil Hidrolasa / Metotrexato / Albúmina Sérica Humana / Anticuerpos / Antimetabolitos Antineoplásicos Límite: Humans Idioma: En Revista: Eur J Pharm Sci Asunto de la revista: FARMACIA / FARMACOLOGIA / QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polietilenglicoles / Profármacos / Gamma-Glutamil Hidrolasa / Metotrexato / Albúmina Sérica Humana / Anticuerpos / Antimetabolitos Antineoplásicos Límite: Humans Idioma: En Revista: Eur J Pharm Sci Asunto de la revista: FARMACIA / FARMACOLOGIA / QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Países Bajos