Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy.

Devisscher, Lars; Van Coillie, Samya; Hofmans, Sam; Van Rompaey, Dries; Goossens, Kenneth; Meul, Eline; Maes, Louis; De Winter, Hans; Van Der Veken, Pieter; Vandenabeele, Peter; Berghe, Tom Vanden; Augustyns, Koen

Devisscher, Lars; Van Coillie, Samya; Hofmans, Sam; Van Rompaey, Dries; Goossens, Kenneth; Meul, Eline; Maes, Louis; De Winter, Hans; Van Der Veken, Pieter; Vandenabeele, Peter; Berghe, Tom Vanden; Augustyns, Koen.

Afiliación

Devisscher L; Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , 2610 Antwerp , Belgium.
Van Coillie S; Molecular Signalling and Cell Death Unit , VIB Center for Inflammation Research , Technologiepark 927 , 9052 Ghent , Belgium.
Hofmans S; Department of Biomedical Molecular Biology , Ghent University , 9000 Ghent , Belgium.
Van Rompaey D; Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , 2610 Antwerp , Belgium.
Goossens K; Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , 2610 Antwerp , Belgium.
Meul E; Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , 2610 Antwerp , Belgium.
Maes L; Molecular Signalling and Cell Death Unit , VIB Center for Inflammation Research , Technologiepark 927 , 9052 Ghent , Belgium.
De Winter H; Department of Biomedical Molecular Biology , Ghent University , 9000 Ghent , Belgium.
Van Der Veken P; Laboratory for Microbiology, Parasitology and Hygiene , University of Antwerp , Universiteitsplein 1 , 2610 Antwerp , Belgium.
Vandenabeele P; Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , 2610 Antwerp , Belgium.
Berghe TV; Laboratory of Medicinal Chemistry , University of Antwerp , Universiteitsplein 1 , 2610 Antwerp , Belgium.
Augustyns K; Molecular Signalling and Cell Death Unit , VIB Center for Inflammation Research , Technologiepark 927 , 9052 Ghent , Belgium.

J Med Chem ; 61(22): 10126-10140, 2018 11 21.

Article en En | MEDLINE | ID: mdl-30354101

Asunto(s)

Apoptosis/efectos de los fármacos; Ciclohexilaminas/metabolismo; Diseño de Fármacos; Fenilendiaminas/metabolismo; Animales; Línea Celular Tumoral; Membrana Celular/efectos de los fármacos; Membrana Celular/metabolismo; Humanos; Ratones; Modelos Moleculares; Conformación Molecular; Estrés Oxidativo/efectos de los fármacos; Ratas; Distribución Tisular

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenilendiaminas / Diseño de Fármacos / Apoptosis / Ciclohexilaminas Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Bélgica

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