Low level of polymyxin resistance among nonclonal mcr-1-positive Escherichia coli from human sources in Brazil.

Pillonetto, Marcelo; Mazzetti, Alana; Becker, Guilherme N; Siebra, Christian A; Arend, Lavinia N V S; Barth, Afonso L

Pillonetto, Marcelo; Mazzetti, Alana; Becker, Guilherme N; Siebra, Christian A; Arend, Lavinia N V S; Barth, Afonso L.

Afiliación

Pillonetto M; State Public Health Laboratory of Paraná, São José dos Pinhais, Brazil; Pontifical Catholic University of Paraná, Curitiba, Brazil; Instituto Nacional de Pesquisa em Resistência Antimicrobiana-INPRA, Brazil. Electronic address: m.pilonetto@pucpr.br.
Mazzetti A; Pontifical Catholic University of Paraná, Curitiba, Brazil.
Becker GN; State Public Health Laboratory of Paraná, São José dos Pinhais, Brazil.
Siebra CA; State Public Health Laboratory of Paraná, São José dos Pinhais, Brazil.
Arend LNVS; State Public Health Laboratory of Paraná, São José dos Pinhais, Brazil.
Barth AL; Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Instituto Nacional de Pesquisa em Resistência Antimicrobiana-INPRA, Brazil.

Diagn Microbiol Infect Dis ; 93(2): 140-142, 2019 Feb.

Article en En | MEDLINE | ID: mdl-30355469

ABSTRACT

ABSTRACT

We report 26 human isolates of mcr-1-positive Escherichia coli, most of them (65.4%) with a polymyxin B MIC of 2â¯mg/L. Seventeen out of the 24 mcr-1-positive E. coli proved to be nonclonal by rep-PCR which strengthens the hypothesis of environmental or animal origin of these strains and reinforces the one health context of antimicrobial resistance.

Asunto(s)

Farmacorresistencia Bacteriana/genética; Infecciones por Escherichia coli/microbiología; Proteínas de Escherichia coli/genética; Escherichia coli/efectos de los fármacos; Polimixinas/farmacología; Antibacterianos/farmacología; Estudios de Cohortes; Escherichia coli/genética; Humanos; Pruebas de Sensibilidad Microbiana

Palabras clave

Antimicrobial resistance; E. coli; One health; Polymyxin resistance; mcr-1

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_neglected_diseases / 3_zoonosis Asunto principal: Polimixinas / Proteínas de Escherichia coli / Farmacorresistencia Bacteriana / Escherichia coli / Infecciones por Escherichia coli Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Humans País/Región como asunto: America do sul / Brasil Idioma: En Revista: Diagn Microbiol Infect Dis Año: 2019 Tipo del documento: Article

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