Nickel deposition and penetration into the stratum corneum after short metallic nickel contact: An experimental study.
Contact Dermatitis
; 80(2): 86-93, 2019 Feb.
Article
en En
| MEDLINE
| ID: mdl-30370609
ABSTRACT
BACKGROUND:
Knowledge about the skin deposition and penetration of nickel into the stratum corneum (SC) after short contact with metallic items is limited.OBJECTIVE:
To quantify nickel skin deposition and penetration into the SC after short contact with metallic nickel.METHODS:
Sixteen nickel-allergic participants and 10 controls were exposed to 3 pure nickel discs and 1 aluminium disc on each volar forearm for 3 × 10 minutes. Before exposure, 1 forearm was irritated with 0.5% sodium lauryl sulfate under 24-hour occlusion. Immediately, as well as 24 and 72 hours after metallic disc exposure, outer SC layers were removed with adhesive tapes and the nickel content was measured.RESULTS:
Nickel deposition and SC penetration capable of eliciting allergic nickel dermatitis were found immediately and after 24 hours. Significantly higher nickel amounts were found on normal skin and in the SC of nickel-allergic participants than in controls both immediately and after 24 hours, and on irritated skin immediately after exposure.CONCLUSIONS:
Nickel deposition and SC penetration is considerable after nickel skin exposure of 3 × 10 minutes. Combined with the allergic responses resulting from the same exposures reported previously, this study highlights that short skin exposure to nickel-releasing items may cause allergic nickel dermatitis.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piel
/
Absorción Cutánea
/
Quelantes
/
Dermatitis Alérgica por Contacto
/
Níquel
Tipo de estudio:
Etiology_studies
Límite:
Adult
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Contact Dermatitis
Año:
2019
Tipo del documento:
Article
País de afiliación:
Dinamarca