RNA-Based Immunostimulatory Liposomal Spherical Nucleic Acids as Potent TLR7/8 Modulators.

Guan, Chenxia; Chernyak, Natalia; Dominguez, Donye; Cole, Lisa; Zhang, Bin; Mirkin, Chad A

Guan, Chenxia; Chernyak, Natalia; Dominguez, Donye; Cole, Lisa; Zhang, Bin; Mirkin, Chad A.

Afiliación

Guan C; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, 60208, USA.
Chernyak N; International Institute for Nanotechnology, Northwestern University, Evanston, IL, 60208, USA.
Dominguez D; International Institute for Nanotechnology, Northwestern University, Evanston, IL, 60208, USA.
Cole L; Department of Chemistry, Northwestern University, Evanston, IL, 60208, USA.
Zhang B; Department of Medicine, Division of Hematology and Oncology, Northwestern University, Chicago, IL, 60611, USA.
Mirkin CA; International Institute for Nanotechnology, Northwestern University, Evanston, IL, 60208, USA.

Small ; 14(49): e1803284, 2018 12.

Article en En | MEDLINE | ID: mdl-30370991

Asunto(s)

Vacunas contra el Cáncer/química; Liposomas/química; Nanopartículas/química; Ácidos Nucleicos/química; Receptor Toll-Like 7/química; Receptor Toll-Like 8/química; Animales; Linfocitos T CD8-positivos/metabolismo; Células Cultivadas; Humanos; Ratones

Palabras clave

SNAs; TLR7/8 agonist; cancer vaccine; immunomodulation; liposome; nanoparticle; spherical nucleic acids

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Nucleicos / Vacunas contra el Cáncer / Receptor Toll-Like 7 / Receptor Toll-Like 8 / Nanopartículas / Liposomas Límite: Animals / Humans Idioma: En Revista: Small Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos

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