A deeper insight into how GABA-B receptor agonism via baclofen may affect alcohol seeking and consumption: lessons learned from a human laboratory investigation.

Farokhnia, Mehdi; Deschaine, Sara L; Sadighi, Armin; Farinelli, Lisa A; Lee, Mary R; Akhlaghi, Fatemeh; Leggio, Lorenzo

Farokhnia, Mehdi; Deschaine, Sara L; Sadighi, Armin; Farinelli, Lisa A; Lee, Mary R; Akhlaghi, Fatemeh; Leggio, Lorenzo.

Afiliación

Farokhnia M; Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism and National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, USA.
Deschaine SL; Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism and National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, USA.
Sadighi A; Clinical Pharmacokinetics Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI, USA.
Farinelli LA; Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism and National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, USA.
Lee MR; Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism and National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, USA.
Akhlaghi F; Clinical Pharmacokinetics Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI, USA.
Leggio L; Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism and National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, USA. lorenzo.leggio@nih.gov.

Mol Psychiatry ; 26(2): 545-555, 2021 02.

Article en En | MEDLINE | ID: mdl-30382188

Asunto(s)

Alcoholismo; Agonistas de Receptores GABA-B; Alcoholismo/tratamiento farmacológico; Baclofeno; Humanos; Laboratorios; Receptores de GABA-B

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 2_ODS3 / 8_ODS3_consumo_sustancias_psicoactivas Problema de salud: 2_sustancias_psicoativas / 8_alcohol Asunto principal: Alcoholismo / Agonistas de Receptores GABA-B Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Revista: Mol Psychiatry Asunto de la revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos

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