Impact of extended working periods on genomic and telomeric DNA and on inflammatory markers: Results of an intervention study with office workers and carpenters.
Mutat Res Genet Toxicol Environ Mutagen
; 836(Pt A): 78-81, 2018 Dec.
Article
en En
| MEDLINE
| ID: mdl-30389166
ABSTRACT
Aim of this study was to clarify if extension of the work phase has an impact on DNA- stability, telomere lengths and inflammatory markers. We conducted an intervention trial with office workers (nâ¯=â¯24) and carpenters (nâ¯=â¯10), who changed their working schedule from 8 to 12â¯h per day over a period of 3 months. The work of both groups involved only moderate physical activity. We found no evidence for induction of double strand breaks (measured in γH2AX assays) and relative telomere lengths (relTL_36B4 and ALB) in lymphocytes in the two study groups. Furthermore, no overall changes of the levels of C-reactive protein (CRP), interleukin-6 (IL-6) and thiobarbituric acid reactive substances (TBARS) in plasma were detected. However, we found in agreement with earlier investigations a moderate (not significant) increase of the CRP levels with age. Furthermore, significant higher CRP concentrations (Pâ¯=â¯0.03) were detected in young individuals (21-30 years) as a consequence of the extended working period. Taken together our findings indicate that prolongation of the working hours has no pronounced impact on DNA stability, telomere shortening and inflammatory markers; but the increase of the CRP concentrations in young workers may be indicative for adverse health effects in this subgroup.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
ADN
/
Telómero
/
Lugar de Trabajo
/
Mediadores de Inflamación
/
Empleo
Aspecto:
Determinantes_sociais_saude
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Mutat Res Genet Toxicol Environ Mutagen
Año:
2018
Tipo del documento:
Article
País de afiliación:
Austria