Role of gut microbiota in intestinal wound healing and barrier function.
Tissue Barriers
; 6(3): 1539595, 2018.
Article
en En
| MEDLINE
| ID: mdl-30404570
ABSTRACT
The mammalian intestine harbors a highly complex and abundant ensemble of bacteria that flourish in a nutrient-rich environment while profoundly influencing many aspects of host biology. The intestine coevolved with its resident microbes in a manner where the mucosa developed a barrier function to segregate the resident microbes from the rest of the body, and yet paradoxically, allowing integration of microbial signals for the host benefit. In this review, we provided a comprehensive overview of why the gut microbiota is key to the efficient development and maintenance of the intestinal barrier. We also highlighted how a destabilized equilibrium between gut microbiota and the host may eventuate in a wide range of intestinal diseases characterized by the disrupted intestinal barrier. Finally, the review delineated how microenvironmental changes in the injured mucosa result in an enrichment of a pro-regenerating consortium of bacteria, which augments mucosal wound repair and restoration of barrier functions.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_zoonosis
Asunto principal:
Cicatrización de Heridas
/
Microbioma Gastrointestinal
/
Mucosa Intestinal
Idioma:
En
Revista:
Tissue Barriers
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos