EGFR confers radioresistance in human oropharyngeal carcinoma by activating endoplasmic reticulum stress signaling PERK-eIF2&#945;-GRP94 and IRE1&#945;-XBP1-GRP78.

Zhang, Miao; Han, Ning; Jiang, Yuanjun; Wang, Jie; Li, Gaiyan; Lv, Xintong; Li, Guang; Qiao, Qiao

EGFR confers radioresistance in human oropharyngeal carcinoma by activating endoplasmic reticulum stress signaling PERK-eIF2α-GRP94 and IRE1α-XBP1-GRP78.

Zhang, Miao; Han, Ning; Jiang, Yuanjun; Wang, Jie; Li, Gaiyan; Lv, Xintong; Li, Guang; Qiao, Qiao.

Afiliación

Zhang M; Department of Radiation Oncology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Han N; Department of Radiation Oncology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Jiang Y; Department of Urology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Wang J; Department of Radiation Oncology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Li G; Department of Radiation Oncology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Lv X; Department of Radiation Oncology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Li G; Department of Radiation Oncology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Qiao Q; Department of Radiation Oncology, The First Hospital of China Medical University, Shenyang, Liaoning, China.

Cancer Med ; 7(12): 6234-6246, 2018 12.

Article en En | MEDLINE | ID: mdl-30414263

Asunto(s)

Estrés del Retículo Endoplásmico; Neoplasias Orofaríngeas/metabolismo; Tolerancia a Radiación; Línea Celular Tumoral; Chaperón BiP del Retículo Endoplásmico; Endorribonucleasas/genética; Endorribonucleasas/metabolismo; Receptores ErbB/metabolismo; Factor 2 Eucariótico de Iniciación/metabolismo; Proteínas de Choque Térmico/metabolismo; Humanos; Glicoproteínas de Membrana/metabolismo; Proteínas Serina-Treonina Quinasas/genética; Proteínas Serina-Treonina Quinasas/metabolismo; Proteína 1 de Unión a la X-Box/metabolismo; eIF-2 Quinasa/genética; eIF-2 Quinasa/metabolismo

Palabras clave

EGFR; ERS; oropharyngeal carcinoma; radiation; radioresistance

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tolerancia a Radiación / Neoplasias Orofaríngeas / Estrés del Retículo Endoplásmico Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cancer Med Año: 2018 Tipo del documento: Article País de afiliación: China

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