Increased zonulin is associated with hyperactivity and social dysfunctions in children with attention deficit hyperactivity disorder.
Compr Psychiatry
; 87: 138-142, 2018 11.
Article
en En
| MEDLINE
| ID: mdl-30414552
ABSTRACT
BACKGROUND:
In attention deficit hyperactivity disorder (ADHD), deteriorations of brain gut axis has been shown in previous studies. One area where the most important challenges are seen in ADHD is social functioning. Zonulin is a protein found in the intestinal intraepithelial component; it has been shown that the level of zonulin increases when intestinal permeability is impaired. Changes in intestinal function were shown in ADHD. Zonulin has been shown to be associated with social impairment in children with autism spectrum disorder. In this study, it was aimed to evaluate the relationship between the ADHD symptoms and zonulin in children with ADHD. Secondarily relation of zonulin and difficulties in social functioning was examined in these children.METHODS:
Forty children diagnosed with ADHD and forty-one healthy children similar age and gender to ADHD group and their mothers were included in the study. Children without any chronic systemic immunological or infectious diseases were included in the case and control group. The ADHD symptoms were scored by the DuPaul ADHD scale and the social functioning of the children was assessed by the Social Responsiveness Scale (SRS). Serum zonulin levels were analyzed by enzyme-linked immunosorbent assay.RESULTS:
Children with ADHD had higher serum zonulin levels and were more impaired in social functioning compared to controls. The level of zonulin was independently predicted with hyperactivity symptoms and SRS scores in regression analysis.CONCLUSION:
In this sample of children with ADHD, elevated zonulin levels were associated with increased symptoms of hyperactivity and impairment of social functioning.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_cholera
Asunto principal:
Trastorno por Déficit de Atención con Hiperactividad
/
Trastorno de la Conducta Social
/
Toxina del Cólera
Tipo de estudio:
Evaluation_studies
/
Observational_studies
/
Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
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Child
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Female
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Humans
/
Male
Idioma:
En
Revista:
Compr Psychiatry
Año:
2018
Tipo del documento:
Article