Two new polyketides isolated from a diethyl sulphate mutant of marine-derived Penicillium purpurogenum G59.
Nat Prod Res
; 33(20): 2977-2981, 2019 Oct.
Article
en En
| MEDLINE
| ID: mdl-30417660
ABSTRACT
Two new polyketides, purpurofuranone (1) and purpuropyranone (2), were isolated along with the known polyketides, cillifuranone (3) and taiwapyrone (4), from a mutant BD-3n-1 derived from the diethyl sulfate (DES) mutagenesis of a marine-derived Penicillium purpurogenum G59. The structures of 1 and 2 were elucidated by spectroscopic methods especially on the basis of X-ray diffraction and calculated optical rotations data. The plausible biosynthesis of 1 - 4 was also proposed and discussed. In preliminary MTT assay, 1 - 4 showed no notable inhibitory effects on the tested four human cancer cell lines.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Penicillium
/
Mutagénesis
/
Policétidos
Límite:
Humans
Idioma:
En
Revista:
Nat Prod Res
Año:
2019
Tipo del documento:
Article
País de afiliación:
China