Polymorphisms of the cytidine deaminase APOBEC3F have different HIV-1 restriction efficiencies.

Mohammadzadeh, Nazanin; Follack, Tyson B; Love, Robin P; Stewart, Kris; Sanche, Stephen; Chelico, Linda

Mohammadzadeh, Nazanin; Follack, Tyson B; Love, Robin P; Stewart, Kris; Sanche, Stephen; Chelico, Linda.

Afiliación

Mohammadzadeh N; University of Saskatchewan, Biochemistry, Microbiology, and Immunology, College of Medicine, Saskatoon, Saskatchewan, Canada.
Follack TB; University of Saskatchewan, Biochemistry, Microbiology, and Immunology, College of Medicine, Saskatoon, Saskatchewan, Canada.
Love RP; University of Saskatchewan, Biochemistry, Microbiology, and Immunology, College of Medicine, Saskatoon, Saskatchewan, Canada.
Stewart K; University of Saskatchewan, Department of Medicine, College of Medicine, Saskatoon, Saskatchewan Canada; Saskatchewan Infectious Disease Care Network, Saskatoon, Saskatchewan, Canada; Saskatchewan HIV/AIDS Research Endeavour, Saskatoon, Saskatchewan, Canada.
Sanche S; University of Saskatchewan, Department of Medicine, College of Medicine, Saskatoon, Saskatchewan Canada; Saskatchewan HIV/AIDS Research Endeavour, Saskatoon, Saskatchewan, Canada.
Chelico L; University of Saskatchewan, Biochemistry, Microbiology, and Immunology, College of Medicine, Saskatoon, Saskatchewan, Canada; Saskatchewan HIV/AIDS Research Endeavour, Saskatoon, Saskatchewan, Canada. Electronic address: linda.chelico@usask.ca.

Virology ; 527: 21-31, 2019 01 15.

Article en En | MEDLINE | ID: mdl-30448640

Asunto(s)

Citosina Desaminasa/genética; Infecciones por VIH/genética; VIH-1/genética; Polimorfismo Genético; Replicación Viral; Desaminasa APOBEC-3G/química; Desaminasa APOBEC-3G/genética; Citosina Desaminasa/química; ADN Viral/genética; Células HEK293; VIH-1/fisiología; Heterocigoto; Humanos; Mutación; Multimerización de Proteína; Estabilidad Proteica; Virión/metabolismo; Productos del Gen vif del Virus de la Inmunodeficiencia Humana/genética; Productos del Gen vif del Virus de la Inmunodeficiencia Humana/metabolismo

Palabras clave

APOBEC3; Deamination; HIV-1; Infectivity; Mutagenesis; Restriction factors; Vif

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Replicación Viral / Infecciones por VIH / VIH-1 / Citosina Desaminasa Límite: Humans Idioma: En Revista: Virology Año: 2019 Tipo del documento: Article País de afiliación: Canadá

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