The microRNA-127-3p directly targeting Vamp2 in C2C12 myoblasts.
Anim Cells Syst (Seoul)
; 22(5): 299-304, 2018.
Article
en En
| MEDLINE
| ID: mdl-30460111
ABSTRACT
MicroRNAs (miRNAs) have been reported that can regulate skeletal muscle growth and development. Previously, we demonstrated that miR-127-3p were differently expressed in skeletal muscle and muscle cells. However, the molecular mechanism of miR-127-3p regulation of skeletal myogenesis are not well elucidated. In this study, we transfected miR-127-3p into C2C12 cells, and found miR-127-3p induces myogenesis by targeting Vamp2. Moreover, the regulatory mechanism of Vamp2 in myoblasts proliferation and differentiation was further confirmed. In conclusion, our data providedevidences that miR-127-3p reciprocally regulated myoblasts proliferation and differentiation through directly targeting Vamp2.
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Colección:
01-internacional
Base de datos:
MEDLINE
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En
Revista:
Anim Cells Syst (Seoul)
Año:
2018
Tipo del documento:
Article