Rapid Determination of Cocaine and Its Metabolite Benzoylecgonine in Hair by LC-MS/MS.
Fa Yi Xue Za Zhi
; 34(4): 375-378, 2018 Aug.
Article
en En, Zh
| MEDLINE
| ID: mdl-30465401
ABSTRACT
OBJECTIVES:
To establish a rapid determination method with LC-MS/MS for cocaine and its metabolite benzoylecgonine in hair.METHODS:
Deuterated internal standards ï¼cocaine-D3 and benzoylecgonine-D8ï¼ were added to the decontaminated hair. After the extraction by ultrasonication with methanol, the compounds were separated by the Restek Allure PFP propyl column, and cocaine and benzoylecgonine were simultaneously analysed in multiple reaction monitoring mode.RESULTS:
The cocaine and benzoylecgonine in hair showed a good linearity in the range of mass fraction between 0.02 and 10.00 ng/mg with the limits of detection of 0.01 ng/mg.CONCLUSIONS:
The developed method is simple and rapid with a good selectivity, which is suitable for the determination of cocaine and its metabolite benzoylecgonine in hair.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cromatografía Liquida
/
Cocaína
/
Espectrometría de Masas en Tándem
/
Cabello
Límite:
Humans
Idioma:
En
/
Zh
Revista:
Fa Yi Xue Za Zhi
Asunto de la revista:
JURISPRUDENCIA
Año:
2018
Tipo del documento:
Article
País de afiliación:
China